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Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88

Muleta, Konjit Getachew LU ; Holst, Signe ; Garcias López, Agnès ; Chakraborty, Sayoni ; da Silva, Clement LU ; Cunningham, Adam F. ; Ulmert, Isabel ; Nakawesi, Joy LU ; Hütter, Julia and Lahl, Katharina LU (2026) In Scandinavian Journal of Immunology 103(4).
Abstract

The initiation of adaptive immunity requires antigen presentation in immune inductive sites. Classical dendritic cells (cDC) sense peripheral immune response inducing cues and migrate to the tissue-draining lymph nodes upon engagement, where they present acquired antigen to cognate T cells. Vaccines include adjuvants, which enable cDC activation and migration, both essential steps in the cascade leading to adaptive immunity. We here show that the expression of MyD88, the adapter molecule downstream of most toll-like receptors (TLR), is essential for the migration of cDCs in response to several stimuli and that its restricted expression to the TLR-sensing cDC subset is sufficient for the migration of that subset. As efficacious oral... (More)

The initiation of adaptive immunity requires antigen presentation in immune inductive sites. Classical dendritic cells (cDC) sense peripheral immune response inducing cues and migrate to the tissue-draining lymph nodes upon engagement, where they present acquired antigen to cognate T cells. Vaccines include adjuvants, which enable cDC activation and migration, both essential steps in the cascade leading to adaptive immunity. We here show that the expression of MyD88, the adapter molecule downstream of most toll-like receptors (TLR), is essential for the migration of cDCs in response to several stimuli and that its restricted expression to the TLR-sensing cDC subset is sufficient for the migration of that subset. As efficacious oral vaccines are primarily needed for use in newborns, we further quantify and characterise neonatal intestinal cDCs in five-day-old mice and show that they follow the same rules and patterns as we identified for cDCs in the adult intestines. Together, our data suggest strong conservation of immune-inducing cues across ages and provide fundamental knowledge aiding adjuvant choice for neonatal vaccination strategies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dendritic cells, intestinal immunity, MyD88, neonates
in
Scandinavian Journal of Immunology
volume
103
issue
4
article number
e70114
publisher
Wiley-Blackwell
external identifiers
  • scopus:105035712678
  • pmid:41981873
ISSN
0300-9475
DOI
10.1111/sji.70114
language
English
LU publication?
yes
id
9091c8a6-fff9-4dc9-95b4-e0c132550a87
date added to LUP
2026-06-24 11:39:48
date last changed
2026-06-25 03:00:08
@article{9091c8a6-fff9-4dc9-95b4-e0c132550a87,
  abstract     = {{<p>The initiation of adaptive immunity requires antigen presentation in immune inductive sites. Classical dendritic cells (cDC) sense peripheral immune response inducing cues and migrate to the tissue-draining lymph nodes upon engagement, where they present acquired antigen to cognate T cells. Vaccines include adjuvants, which enable cDC activation and migration, both essential steps in the cascade leading to adaptive immunity. We here show that the expression of MyD88, the adapter molecule downstream of most toll-like receptors (TLR), is essential for the migration of cDCs in response to several stimuli and that its restricted expression to the TLR-sensing cDC subset is sufficient for the migration of that subset. As efficacious oral vaccines are primarily needed for use in newborns, we further quantify and characterise neonatal intestinal cDCs in five-day-old mice and show that they follow the same rules and patterns as we identified for cDCs in the adult intestines. Together, our data suggest strong conservation of immune-inducing cues across ages and provide fundamental knowledge aiding adjuvant choice for neonatal vaccination strategies.</p>}},
  author       = {{Muleta, Konjit Getachew and Holst, Signe and Garcias López, Agnès and Chakraborty, Sayoni and da Silva, Clement and Cunningham, Adam F. and Ulmert, Isabel and Nakawesi, Joy and Hütter, Julia and Lahl, Katharina}},
  issn         = {{0300-9475}},
  keywords     = {{dendritic cells; intestinal immunity; MyD88; neonates}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Scandinavian Journal of Immunology}},
  title        = {{Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88}},
  url          = {{http://dx.doi.org/10.1111/sji.70114}},
  doi          = {{10.1111/sji.70114}},
  volume       = {{103}},
  year         = {{2026}},
}