Orthostatic Hypertension : Critical Appraisal of an Overlooked Condition
Jordan, Jens ; Ricci, Fabrizio LU ; Hoffmann, Fabian ; Hamrefors, Viktor LU
and Fedorowski, Artur
LU
(2020)
In Hypertension
75(5).
p.1151-1158
- Abstract
Orthostatic hypertension, which appears to be mediated through excess neurohumoral activation while standing, is a common blood pressure trait among patients with and without arterial hypertension. However, lack of consensus regarding the definition of orthostatic hypertension makes it difficult to assess the true prevalence of this condition. Orthostatic hypertension appears to predict the risk for progression to arterial hypertension in younger and risk of cardiovascular morbidity and mortality in older persons. Yet, the risk may differ between populations. Whether orthostatic hypertension indicates a generally increased risk of death, constitutes an intermediate variable in the causal pathway of cardiovascular risk factors, a simple... (More)
Orthostatic hypertension, which appears to be mediated through excess neurohumoral activation while standing, is a common blood pressure trait among patients with and without arterial hypertension. However, lack of consensus regarding the definition of orthostatic hypertension makes it difficult to assess the true prevalence of this condition. Orthostatic hypertension appears to predict the risk for progression to arterial hypertension in younger and risk of cardiovascular morbidity and mortality in older persons. Yet, the risk may differ between populations. Whether orthostatic hypertension indicates a generally increased risk of death, constitutes an intermediate variable in the causal pathway of cardiovascular risk factors, a simple measure of disease severity, or an independently acting mechanism is not known. Since both orthostatic hypotension and orthostatic hypertension herald increased risk of cardiovascular disease, it appears reasonable to screen the patients for abnormal orthostatic blood pressure responses using simple orthostatic testing. However, how presence of orthostatic hypertension may affect clinical management decisions such as the choice of antihypertensive drugs is currently difficult to ascertain. Clearly, this issue deserves more attention.
(Less)
- author
- Jordan, Jens
; Ricci, Fabrizio
LU
; Hoffmann, Fabian
; Hamrefors, Viktor
LU
and Fedorowski, Artur
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Hypertension
- volume
- 75
- issue
- 5
- pages
- 1151 - 1158
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:32223382
- scopus:85083084726
- ISSN
- 1524-4563
- DOI
- 10.1161/HYPERTENSIONAHA.120.14340
- language
- English
- LU publication?
- yes
- id
- 9376f8ae-d8a1-431b-8ac3-32285829ea81
- date added to LUP
- 2020-04-07 08:16:48
- date last changed
- 2024-06-12 11:35:27
@article{9376f8ae-d8a1-431b-8ac3-32285829ea81,
abstract = {{<p>Orthostatic hypertension, which appears to be mediated through excess neurohumoral activation while standing, is a common blood pressure trait among patients with and without arterial hypertension. However, lack of consensus regarding the definition of orthostatic hypertension makes it difficult to assess the true prevalence of this condition. Orthostatic hypertension appears to predict the risk for progression to arterial hypertension in younger and risk of cardiovascular morbidity and mortality in older persons. Yet, the risk may differ between populations. Whether orthostatic hypertension indicates a generally increased risk of death, constitutes an intermediate variable in the causal pathway of cardiovascular risk factors, a simple measure of disease severity, or an independently acting mechanism is not known. Since both orthostatic hypotension and orthostatic hypertension herald increased risk of cardiovascular disease, it appears reasonable to screen the patients for abnormal orthostatic blood pressure responses using simple orthostatic testing. However, how presence of orthostatic hypertension may affect clinical management decisions such as the choice of antihypertensive drugs is currently difficult to ascertain. Clearly, this issue deserves more attention.</p>}},
author = {{Jordan, Jens and Ricci, Fabrizio and Hoffmann, Fabian and Hamrefors, Viktor and Fedorowski, Artur}},
issn = {{1524-4563}},
language = {{eng}},
number = {{5}},
pages = {{1151--1158}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Hypertension}},
title = {{Orthostatic Hypertension : Critical Appraisal of an Overlooked Condition}},
url = {{http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14340}},
doi = {{10.1161/HYPERTENSIONAHA.120.14340}},
volume = {{75}},
year = {{2020}},
}