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Superinduction of cytokine gene transcription by ciprofloxacin

Riesbeck, Kristian LU orcid ; Sigvardsson, Mikael LU ; Leanderson, Tomas LU and Forsgren, Arne LU (1994) In Journal of Immunology 153(1). p.343-352
Abstract

In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1)... (More)

In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1) and AP-1 were also found to be increased by ciprofloxacin. Thus, ciprofloxacin interferes with a regulative pathway common to several cytokines.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
153
issue
1
pages
343 - 352
publisher
American Association of Immunologists
external identifiers
  • pmid:8207247
  • scopus:0028283009
ISSN
0022-1767
language
English
LU publication?
yes
id
a1dac134-76fe-40f9-87d8-a75163897048
alternative location
http://www.jimmunol.org/content/153/1/343
date added to LUP
2019-03-29 11:48:41
date last changed
2025-10-14 08:54:31
@article{a1dac134-76fe-40f9-87d8-a75163897048,
  abstract     = {{<p>In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-γ production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1α, IL-2 and its receptor, IFN-γ, IL-3, IL-4, granulocyte- macrophage/CSF, TNF-α, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1) and AP-1 were also found to be increased by ciprofloxacin. Thus, ciprofloxacin interferes with a regulative pathway common to several cytokines.</p>}},
  author       = {{Riesbeck, Kristian and Sigvardsson, Mikael and Leanderson, Tomas and Forsgren, Arne}},
  issn         = {{0022-1767}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  pages        = {{343--352}},
  publisher    = {{American Association of Immunologists}},
  series       = {{Journal of Immunology}},
  title        = {{Superinduction of cytokine gene transcription by ciprofloxacin}},
  url          = {{http://www.jimmunol.org/content/153/1/343}},
  volume       = {{153}},
  year         = {{1994}},
}