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Variations over time in proximal femoral strength in young adult men are not explained by areal bone mineral density alone

Attar, Shoaib LU ; Isaksson, Hanna LU orcid ; Jehpsson, Lars LU ; Rosengren, Bjorn E LU ; Karlsson, Magnus K LU and Grassi, Lorenzo LU orcid (2025) In JBMR Plus 9(10).
Abstract

The decline in areal BMD (aBMD) in men may start as early as age 19, but it is debated whether proximal femoral strength follows the same pattern. We measured FN aBMD in a cross-sectional cohort of 1101 men aged 18-28 yr with two-dimensional DXA. Body height, weight, jump height, grip strength, and maximum knee extension torque muscle strength were measured with standard tests, after which BMI was calculated. We adopted a validated method to automatically obtain three-dimensional finite element (FE) models from 2D DXA images and predict proximal femoral strength. We compared FN aBMD and FE-predicted proximal femoral strength as a function of age. Linear mixed-effect models (LMEs) were used to evaluate the association between age (whole... (More)

The decline in areal BMD (aBMD) in men may start as early as age 19, but it is debated whether proximal femoral strength follows the same pattern. We measured FN aBMD in a cross-sectional cohort of 1101 men aged 18-28 yr with two-dimensional DXA. Body height, weight, jump height, grip strength, and maximum knee extension torque muscle strength were measured with standard tests, after which BMI was calculated. We adopted a validated method to automatically obtain three-dimensional finite element (FE) models from 2D DXA images and predict proximal femoral strength. We compared FN aBMD and FE-predicted proximal femoral strength as a function of age. Linear mixed-effect models (LMEs) were used to evaluate the association between age (whole years), FN aBMD, FN area, jump height, grip strength, maximum knee extension torque, and FE-predicted proximal femoral strength. A negative correlation (
r  = -0.10,
p  = .001) was observed between FN aBMD and age between ages 18 and 28; no statistically significant correlation (
r  = -0.02,
p  = .55) between age and FE-predicted proximal femoral strength was found. There was a positive correlation between FE-predicted proximal femoral strength and the subjects' height (
r  = 0.22,
p  < .001) and weight (
r  = 0.35,
p  < .001). Higher jump height (
r  = 0.13,
p  < .001), grip strength (
r  = 0.23,
p  < .001), and maximum knee extension torque (
r  = 0.31,
p  < .001) were associated with higher FE-predicted proximal femoral strength. Femoral neck aBMD, FN area, and body height explained ~78% of the variations in proximal femoral strength in the LMEs. The inter-subject variations in proximal femoral strength were associated with FN aBMD, FN area, body height, and higher outcomes in jump height, grip strength, and maximum knee extension torque.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JBMR Plus
volume
9
issue
10
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:40978123
  • scopus:105016393748
ISSN
2473-4039
DOI
10.1093/jbmrpl/ziaf136
project
In silico models to detect developmental hip dysplasia and prevent osteoarthritis
PhD Project: Investigation of the link between hip pathologies during growth and osteoarthritis
Early quantification of hip-related abnormalities in children using statistical shape models
language
English
LU publication?
yes
additional info
© The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.
id
a2805025-73de-4daa-bc8f-23eab310dcb7
date added to LUP
2025-09-29 08:24:15
date last changed
2025-11-25 08:54:07
@article{a2805025-73de-4daa-bc8f-23eab310dcb7,
  abstract     = {{<p>The decline in areal BMD (aBMD) in men may start as early as age 19, but it is debated whether proximal femoral strength follows the same pattern. We measured FN aBMD in a cross-sectional cohort of 1101 men aged 18-28 yr with two-dimensional DXA. Body height, weight, jump height, grip strength, and maximum knee extension torque muscle strength were measured with standard tests, after which BMI was calculated. We adopted a validated method to automatically obtain three-dimensional finite element (FE) models from 2D DXA images and predict proximal femoral strength. We compared FN aBMD and FE-predicted proximal femoral strength as a function of age. Linear mixed-effect models (LMEs) were used to evaluate the association between age (whole years), FN aBMD, FN area, jump height, grip strength, maximum knee extension torque, and FE-predicted proximal femoral strength. A negative correlation (<br>
 r  = -0.10, <br>
 p  = .001) was observed between FN aBMD and age between ages 18 and 28; no statistically significant correlation ( <br>
 r  = -0.02, <br>
 p  = .55) between age and FE-predicted proximal femoral strength was found. There was a positive correlation between FE-predicted proximal femoral strength and the subjects' height ( <br>
 r  = 0.22, <br>
 p  &lt; .001) and weight ( <br>
 r  = 0.35, <br>
 p  &lt; .001). Higher jump height ( <br>
 r  = 0.13, <br>
 p  &lt; .001), grip strength ( <br>
 r  = 0.23, <br>
 p  &lt; .001), and maximum knee extension torque ( <br>
 r  = 0.31, <br>
 p  &lt; .001) were associated with higher FE-predicted proximal femoral strength. Femoral neck aBMD, FN area, and body height explained ~78% of the variations in proximal femoral strength in the LMEs. The inter-subject variations in proximal femoral strength were associated with FN aBMD, FN area, body height, and higher outcomes in jump height, grip strength, and maximum knee extension torque.<br>
 </p>}},
  author       = {{Attar, Shoaib and Isaksson, Hanna and Jehpsson, Lars and Rosengren, Bjorn E and Karlsson, Magnus K and Grassi, Lorenzo}},
  issn         = {{2473-4039}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{JBMR Plus}},
  title        = {{Variations over time in proximal femoral strength in young adult men are not explained by areal bone mineral density alone}},
  url          = {{http://dx.doi.org/10.1093/jbmrpl/ziaf136}},
  doi          = {{10.1093/jbmrpl/ziaf136}},
  volume       = {{9}},
  year         = {{2025}},
}