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Optical tuning of copolymer-in-oil tissue-mimicking materials for multispectral photoacoustic imaging

Khodaverdi, Azin LU ; Cinthio, Magnus LU ; Reistad, Esbjörn ; Erlöv, Tobias LU ; Malmsjö, Malin LU ; Zackrisson, Sophia LU and Reistad, Nina LU orcid (2024) In Biomedical Physics Engineering Express 10(5).
Abstract

OBJECTIVE: The availability of tissue-mimicking materials (TMMs) for manufacturing high-quality phantoms is crucial for standardization, evaluating novel quantitative approaches, and clinically translating new imaging modalities, such as photoacoustic imaging (PAI). Recently, a gel comprising the copolymer styrene-ethylene/butylene-styrene (SEBS) in mineral oil has shown significant potential as TMM due to its optical and acoustic properties akin to soft tissue. We propose using artists' oil-based inks dissolved and diluted in balsam turpentine to tune the optical properties.

APPROACH: A TMM was fabricated by mixing a SEBS copolymer and mineral oil, supplemented with additives to tune its optical absorption and scattering... (More)

OBJECTIVE: The availability of tissue-mimicking materials (TMMs) for manufacturing high-quality phantoms is crucial for standardization, evaluating novel quantitative approaches, and clinically translating new imaging modalities, such as photoacoustic imaging (PAI). Recently, a gel comprising the copolymer styrene-ethylene/butylene-styrene (SEBS) in mineral oil has shown significant potential as TMM due to its optical and acoustic properties akin to soft tissue. We propose using artists' oil-based inks dissolved and diluted in balsam turpentine to tune the optical properties.

APPROACH: A TMM was fabricated by mixing a SEBS copolymer and mineral oil, supplemented with additives to tune its optical absorption and scattering properties independently. A systematic investigation of the tuning accuracies and relationships between concentrations of oil-based pigments and optical absorption properties of the TMM across visible and near-infrared wavelengths using collimated transmission spectroscopy was conducted. The photoacoustic spectrum of various oil-based inks was studied to analyze the effect of increasing concentration and depth.

MAIN RESULTS: Artists' Oil-based inks dissolved in turpentine proved effective as additives to tune the optical absorption properties of mineral oil SEBS-gel with high accuracy. The TMMs demonstrated long-term stability and suitability for producing phantoms with desired optical absorption properties for PAI studies.

SIGNIFICANCE: The findings, including tuning of optical absorption and spectral shape, suggest that this TMM facilitates the development of more sophisticated phantoms of arbitrary shapes. This approach holds promise for advancing the development of PAI, including investigation of the spectral coloring effect. In addition, it can potentially aid in the development and clinical translation of ultrasound optical tomography.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomedical Physics Engineering Express
volume
10
issue
5
article number
055009
pages
16 pages
publisher
IOP Publishing
external identifiers
  • scopus:85198907080
  • pmid:38959869
ISSN
2057-1976
DOI
10.1088/2057-1976/ad5e85
language
English
LU publication?
yes
additional info
Creative Commons Attribution license.
id
ade27367-44d1-493b-b9ab-b0ce1a2d3e02
date added to LUP
2024-07-16 16:44:03
date last changed
2024-09-09 07:40:17
@article{ade27367-44d1-493b-b9ab-b0ce1a2d3e02,
  abstract     = {{<p>OBJECTIVE: The availability of tissue-mimicking materials (TMMs) for manufacturing high-quality phantoms is crucial for standardization, evaluating novel quantitative approaches, and clinically translating new imaging modalities, such as photoacoustic imaging (PAI). Recently, a gel comprising the copolymer styrene-ethylene/butylene-styrene (SEBS) in mineral oil has shown significant potential as TMM due to its optical and acoustic properties akin to soft tissue. We propose using artists' oil-based inks dissolved and diluted in balsam turpentine to tune the optical properties.</p><p>APPROACH: A TMM was fabricated by mixing a SEBS copolymer and mineral oil, supplemented with additives to tune its optical absorption and scattering properties independently. A systematic investigation of the tuning accuracies and relationships between concentrations of oil-based pigments and optical absorption properties of the TMM across visible and near-infrared wavelengths using collimated transmission spectroscopy was conducted. The photoacoustic spectrum of various oil-based inks was studied to analyze the effect of increasing concentration and depth.</p><p>MAIN RESULTS: Artists' Oil-based inks dissolved in turpentine proved effective as additives to tune the optical absorption properties of mineral oil SEBS-gel with high accuracy. The TMMs demonstrated long-term stability and suitability for producing phantoms with desired optical absorption properties for PAI studies.</p><p>SIGNIFICANCE: The findings, including tuning of optical absorption and spectral shape, suggest that this TMM facilitates the development of more sophisticated phantoms of arbitrary shapes. This approach holds promise for advancing the development of PAI, including investigation of the spectral coloring effect. In addition, it can potentially aid in the development and clinical translation of ultrasound optical tomography.</p>}},
  author       = {{Khodaverdi, Azin and Cinthio, Magnus and Reistad, Esbjörn and Erlöv, Tobias and Malmsjö, Malin and Zackrisson, Sophia and Reistad, Nina}},
  issn         = {{2057-1976}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{5}},
  publisher    = {{IOP Publishing}},
  series       = {{Biomedical Physics Engineering Express}},
  title        = {{Optical tuning of copolymer-in-oil tissue-mimicking materials for multispectral photoacoustic imaging}},
  url          = {{http://dx.doi.org/10.1088/2057-1976/ad5e85}},
  doi          = {{10.1088/2057-1976/ad5e85}},
  volume       = {{10}},
  year         = {{2024}},
}