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Mortality risks associated with sibling heart failure

Lindgren, Magnus P. LU ; Ji, Jianguang LU orcid ; Smith, J. Gustav LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Zöller, Bengt LU orcid (2020) In International Journal of Cardiology 307. p.114-118
Abstract
Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with cardiomyopathy or congenital heart disease were excluded. Mortality hazard ratios (HRs) were calculated for siblings of individuals who had been diagnosed with HF compared with siblings of individuals unaffected by HF as the reference group. Similar analyses were made for spouses. HRs were determined for overall mortality, cardiovascular mortality,... (More)
Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with cardiomyopathy or congenital heart disease were excluded. Mortality hazard ratios (HRs) were calculated for siblings of individuals who had been diagnosed with HF compared with siblings of individuals unaffected by HF as the reference group. Similar analyses were made for spouses. HRs were determined for overall mortality, cardiovascular mortality, and death of unknown cause. Results Among siblings, the adjusted HR for overall mortality was 1.21 (95% CI 1.18–1.25). This risk remained (HR = 1.19, 95% CI 1.15–1.23) also among subjects without HF themselves. The adjusted HRs for cardiovascular mortality and death of unknown cause were 1.39 (95% CI 1.32–1.45) and 1.58 (95% CI 1.29–1.95), respectively. The mortality risk associations with spousal HF were all minimal, with an overall mortality HR of 1.02 (1.01–1.02). Early sibling age of onset of HF (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Heart failure, Family history, Mortality, Genetics, Epidemiology
in
International Journal of Cardiology
volume
307
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:31735364
  • scopus:85075415491
ISSN
0167-5273
DOI
10.1016/j.ijcard.2019.10.022
language
English
LU publication?
yes
id
c4651b0e-9972-443e-863b-b14d5ebb2da5
date added to LUP
2019-11-07 14:14:07
date last changed
2022-04-18 18:40:39
@article{c4651b0e-9972-443e-863b-b14d5ebb2da5,
  abstract     = {{Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with cardiomyopathy or congenital heart disease were excluded. Mortality hazard ratios (HRs) were calculated for siblings of individuals who had been diagnosed with HF compared with siblings of individuals unaffected by HF as the reference group. Similar analyses were made for spouses. HRs were determined for overall mortality, cardiovascular mortality, and death of unknown cause. Results Among siblings, the adjusted HR for overall mortality was 1.21 (95% CI 1.18–1.25). This risk remained (HR = 1.19, 95% CI 1.15–1.23) also among subjects without HF themselves. The adjusted HRs for cardiovascular mortality and death of unknown cause were 1.39 (95% CI 1.32–1.45) and 1.58 (95% CI 1.29–1.95), respectively. The mortality risk associations with spousal HF were all minimal, with an overall mortality HR of 1.02 (1.01–1.02). Early sibling age of onset of HF}},
  author       = {{Lindgren, Magnus P. and Ji, Jianguang and Smith, J. Gustav and Sundquist, Jan and Sundquist, Kristina and Zöller, Bengt}},
  issn         = {{0167-5273}},
  keywords     = {{Heart failure; Family history; Mortality; Genetics; Epidemiology}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{114--118}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{Mortality risks associated with sibling heart failure}},
  url          = {{http://dx.doi.org/10.1016/j.ijcard.2019.10.022}},
  doi          = {{10.1016/j.ijcard.2019.10.022}},
  volume       = {{307}},
  year         = {{2020}},
}