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Normal frequency of structural chromosome aberrations in fibroblasts from patients with non‐Hodgkin's lymphoma

JOHANSSON, BERTIL LU ; MERTENS, FREDRIK LU ; HEIM, SVERRE LU ; KRISTOFFERSSON, ULF LU ; MANDAHL, NILS LU ; OLSSON, HÅKAN LU orcid and MITELMAN, FELIX LU orcid (1988) In Hereditas 109(2). p.277-280
Abstract

The incidence of chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in cultured skin fibroblasts from 25 untreated patients with non‐Hodgkin's lymphoma (NHL) and 26 controls. The mean frequencies of aberrant cells, and gap, break, and gap+break events per 100 metaphases were 4.2, 1.9, 2.8, and 4.7 in the NHL group, and 5.1, 2.6, 3.2, and 5.8 in the control group. None of these parameters differed significantly between the groups, indicating that constitutional chromosomal instability is not related to the development of NHL. In the total material there was a significant (P<0.05) increase with age in the number of aberrant cells.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hereditas
volume
109
issue
2
pages
277 - 280
publisher
Wiley-Blackwell
external identifiers
  • scopus:0024229155
  • pmid:3230028
ISSN
0018-0661
DOI
10.1111/j.1601-5223.1988.tb00365.x
language
English
LU publication?
yes
id
c76ffa6d-89a4-4c4f-a5fe-a85225533726
date added to LUP
2018-12-17 17:01:38
date last changed
2024-01-15 10:05:58
@article{c76ffa6d-89a4-4c4f-a5fe-a85225533726,
  abstract     = {{<p>The incidence of chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in cultured skin fibroblasts from 25 untreated patients with non‐Hodgkin's lymphoma (NHL) and 26 controls. The mean frequencies of aberrant cells, and gap, break, and gap+break events per 100 metaphases were 4.2, 1.9, 2.8, and 4.7 in the NHL group, and 5.1, 2.6, 3.2, and 5.8 in the control group. None of these parameters differed significantly between the groups, indicating that constitutional chromosomal instability is not related to the development of NHL. In the total material there was a significant (P&lt;0.05) increase with age in the number of aberrant cells.</p>}},
  author       = {{JOHANSSON, BERTIL and MERTENS, FREDRIK and HEIM, SVERRE and KRISTOFFERSSON, ULF and MANDAHL, NILS and OLSSON, HÅKAN and MITELMAN, FELIX}},
  issn         = {{0018-0661}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  pages        = {{277--280}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Hereditas}},
  title        = {{Normal frequency of structural chromosome aberrations in fibroblasts from patients with non‐Hodgkin's lymphoma}},
  url          = {{http://dx.doi.org/10.1111/j.1601-5223.1988.tb00365.x}},
  doi          = {{10.1111/j.1601-5223.1988.tb00365.x}},
  volume       = {{109}},
  year         = {{1988}},
}