Anthropometric measures and the risk of developing atrial fibrillation : a Swedish Cohort Study
(2021) In BMC Cardiovascular Disorders 21(1).- Abstract
Aims: Obesity is a risk factor for several cardiovascular diseases (CVDs), including atrial fibrillation (AF). However, it is less clear whether overall fat or abdominal fat distribution are most important for risk of developing AF. This study investigates how different anthropometric measures correlate to the risk of developing clinical AF in the Malmö Diet and Cancer cohort (MDC-cohort). Methods: The MDC-cohort (n = 25,961) was examined in 1991–1996. The endpoint was clinical AF diagnosed in a hospital setting, and retrieved via linkage with national registers. Hazard Ratios (HR) for incident AF was calculated in relation to quartiles of body mass index (BMI), waist circumference, waist hip ratio, waist height ratio, body fat... (More)
Aims: Obesity is a risk factor for several cardiovascular diseases (CVDs), including atrial fibrillation (AF). However, it is less clear whether overall fat or abdominal fat distribution are most important for risk of developing AF. This study investigates how different anthropometric measures correlate to the risk of developing clinical AF in the Malmö Diet and Cancer cohort (MDC-cohort). Methods: The MDC-cohort (n = 25,961) was examined in 1991–1996. The endpoint was clinical AF diagnosed in a hospital setting, and retrieved via linkage with national registers. Hazard Ratios (HR) for incident AF was calculated in relation to quartiles of body mass index (BMI), waist circumference, waist hip ratio, waist height ratio, body fat percentage, weight and height, using Cox regression with adjustment for age, biological (e.g. blood pressure, diabetes, blood lipid levels), and socioeconomic risk factors. Results: After adjustment for multiple risk factors, the risk of AF was significantly increased in the 4th versus 1st quartile of weight (HR for men/women = 2.02/1.93), BMI (HR = 1.62/1.52), waist circumference (HR = 1.67/1.63), waist to hip ratio (HR = 1.30/1.24), waist to height ratio (1.37/1.39) and body fat percentage (HR = 1.21/1.45) in men/women. Measures of overall weight (BMI, weight) were slightly more predictive than measures of abdominal obesity (waist hip ratio and waist height ratio) both in men and women. Conclusion: All measures of obesity were associated with increased risk of developing AF. Both overall obesity and abdominal obesity were related to incidence of AF in this population-based study, although the relationship for overall obesity was stronger.
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- author
- Zia, Isac ; Johnson, Linda LU ; Memarian, Ensieh LU ; Borné, Yan LU and Engström, Gunnar LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anthropometric measures, Atrial fibrillation, BMI, Hazards ratio, Obesity
- in
- BMC Cardiovascular Disorders
- volume
- 21
- issue
- 1
- article number
- 602
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:34922449
- scopus:85121443937
- ISSN
- 1471-2261
- DOI
- 10.1186/s12872-021-02415-6
- language
- English
- LU publication?
- yes
- id
- dc03fb75-ef6c-4b71-8e5d-f99a8b6da333
- date added to LUP
- 2022-01-26 14:46:10
- date last changed
- 2024-09-08 08:33:57
@article{dc03fb75-ef6c-4b71-8e5d-f99a8b6da333,
abstract = {{<p>Aims: Obesity is a risk factor for several cardiovascular diseases (CVDs), including atrial fibrillation (AF). However, it is less clear whether overall fat or abdominal fat distribution are most important for risk of developing AF. This study investigates how different anthropometric measures correlate to the risk of developing clinical AF in the Malmö Diet and Cancer cohort (MDC-cohort). Methods: The MDC-cohort (n = 25,961) was examined in 1991–1996. The endpoint was clinical AF diagnosed in a hospital setting, and retrieved via linkage with national registers. Hazard Ratios (HR) for incident AF was calculated in relation to quartiles of body mass index (BMI), waist circumference, waist hip ratio, waist height ratio, body fat percentage, weight and height, using Cox regression with adjustment for age, biological (e.g. blood pressure, diabetes, blood lipid levels), and socioeconomic risk factors. Results: After adjustment for multiple risk factors, the risk of AF was significantly increased in the 4th versus 1st quartile of weight (HR for men/women = 2.02/1.93), BMI (HR = 1.62/1.52), waist circumference (HR = 1.67/1.63), waist to hip ratio (HR = 1.30/1.24), waist to height ratio (1.37/1.39) and body fat percentage (HR = 1.21/1.45) in men/women. Measures of overall weight (BMI, weight) were slightly more predictive than measures of abdominal obesity (waist hip ratio and waist height ratio) both in men and women. Conclusion: All measures of obesity were associated with increased risk of developing AF. Both overall obesity and abdominal obesity were related to incidence of AF in this population-based study, although the relationship for overall obesity was stronger.</p>}},
author = {{Zia, Isac and Johnson, Linda and Memarian, Ensieh and Borné, Yan and Engström, Gunnar}},
issn = {{1471-2261}},
keywords = {{Anthropometric measures; Atrial fibrillation; BMI; Hazards ratio; Obesity}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cardiovascular Disorders}},
title = {{Anthropometric measures and the risk of developing atrial fibrillation : a Swedish Cohort Study}},
url = {{http://dx.doi.org/10.1186/s12872-021-02415-6}},
doi = {{10.1186/s12872-021-02415-6}},
volume = {{21}},
year = {{2021}},
}