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Cardiovascular risk in non-alcoholic fatty liver disease : Mechanisms and therapeutic implications

Tana, Claudio ; Ballestri, Stefano ; Ricci, Fabrizio LU ; Di Vincenzo, Angelo ; Ticinesi, Andrea ; Gallina, Sabina ; Giamberardino, Maria Adele ; Cipollone, Francesco ; Sutton, Richard and Vettor, Roberto , et al. (2019) In International Journal of Environmental Research and Public Health 16(17).
Abstract

New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD... (More)

New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease, Cardiovascular risk factors, Metabolic syndrome, Non-alcoholic fatty liver disease
in
International Journal of Environmental Research and Public Health
volume
16
issue
17
article number
3104
publisher
MDPI AG
external identifiers
  • scopus:85071648224
  • pmid:31455011
ISSN
1661-7827
DOI
10.3390/ijerph16173104
language
English
LU publication?
yes
id
e186ef3b-07bb-4a84-af49-cd7e69a14619
date added to LUP
2019-09-17 13:27:14
date last changed
2024-05-15 19:59:01
@article{e186ef3b-07bb-4a84-af49-cd7e69a14619,
  abstract     = {{<p>New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.</p>}},
  author       = {{Tana, Claudio and Ballestri, Stefano and Ricci, Fabrizio and Di Vincenzo, Angelo and Ticinesi, Andrea and Gallina, Sabina and Giamberardino, Maria Adele and Cipollone, Francesco and Sutton, Richard and Vettor, Roberto and Fedorowski, Artur and Meschi, Tiziana}},
  issn         = {{1661-7827}},
  keywords     = {{Cardiovascular disease; Cardiovascular risk factors; Metabolic syndrome; Non-alcoholic fatty liver disease}},
  language     = {{eng}},
  number       = {{17}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Environmental Research and Public Health}},
  title        = {{Cardiovascular risk in non-alcoholic fatty liver disease : Mechanisms and therapeutic implications}},
  url          = {{http://dx.doi.org/10.3390/ijerph16173104}},
  doi          = {{10.3390/ijerph16173104}},
  volume       = {{16}},
  year         = {{2019}},
}