Cardiovascular risk in non-alcoholic fatty liver disease : Mechanisms and therapeutic implications
(2019) In International Journal of Environmental Research and Public Health 16(17).- Abstract
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD... (More)
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.
(Less)
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiovascular disease, Cardiovascular risk factors, Metabolic syndrome, Non-alcoholic fatty liver disease
- in
- International Journal of Environmental Research and Public Health
- volume
- 16
- issue
- 17
- article number
- 3104
- publisher
- MDPI AG
- external identifiers
-
- scopus:85071648224
- pmid:31455011
- ISSN
- 1661-7827
- DOI
- 10.3390/ijerph16173104
- language
- English
- LU publication?
- yes
- id
- e186ef3b-07bb-4a84-af49-cd7e69a14619
- date added to LUP
- 2019-09-17 13:27:14
- date last changed
- 2024-05-15 19:59:01
@article{e186ef3b-07bb-4a84-af49-cd7e69a14619, abstract = {{<p>New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.</p>}}, author = {{Tana, Claudio and Ballestri, Stefano and Ricci, Fabrizio and Di Vincenzo, Angelo and Ticinesi, Andrea and Gallina, Sabina and Giamberardino, Maria Adele and Cipollone, Francesco and Sutton, Richard and Vettor, Roberto and Fedorowski, Artur and Meschi, Tiziana}}, issn = {{1661-7827}}, keywords = {{Cardiovascular disease; Cardiovascular risk factors; Metabolic syndrome; Non-alcoholic fatty liver disease}}, language = {{eng}}, number = {{17}}, publisher = {{MDPI AG}}, series = {{International Journal of Environmental Research and Public Health}}, title = {{Cardiovascular risk in non-alcoholic fatty liver disease : Mechanisms and therapeutic implications}}, url = {{http://dx.doi.org/10.3390/ijerph16173104}}, doi = {{10.3390/ijerph16173104}}, volume = {{16}}, year = {{2019}}, }