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Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

Yadav, Vikas LU orcid ; Singh, Tejveer ; Sharma, Deepika ; Garg, Vivek Kumar ; Chakraborty, Payel LU ; Ghatak, Souvik LU and Satapathy, Shakti Ranjan LU (2024) In Cancers 16(18).
Abstract
Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R (HuR) is a prominent RBP known to drive tumorigenesis with a pivotal role in CRC. In this review, we discuss the regulatory role of the HuR/miRNA axis in CRC. Interestingly, miRNAs can directly target HuR, altering its expression and activity. However, HuR can also stabilize or degrade miRNAs, forming complex feedback loops that either activate... (More)
Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R (HuR) is a prominent RBP known to drive tumorigenesis with a pivotal role in CRC. In this review, we discuss the regulatory role of the HuR/miRNA axis in CRC. Interestingly, miRNAs can directly target HuR, altering its expression and activity. However, HuR can also stabilize or degrade miRNAs, forming complex feedback loops that either activate or block CRC-associated signaling pathways. Dysregulation of the HuR/miRNA axis contributes to CRC initiation and progression. Additionally, HuR-miRNA regulation by other small non-coding RNAs, circular RNA (circRNAs), or long-non-coding RNAs (lncRNAs) is also explored here. Understanding this HuR-miRNA interplay could reveal novel biomarkers with better diagnostic or prognostic accuracy. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
microRNA, lncRNA, circular RNA, RNA-binding protein, HuR, colorectal cancer
in
Cancers
volume
16
issue
18
article number
3183
pages
21 pages
publisher
MDPI AG
external identifiers
  • pmid:39335155
  • scopus:85205236580
ISSN
2072-6694
DOI
10.3390/cancers16183183
language
English
LU publication?
yes
id
e3c788b1-df2c-4501-bd4c-b465e232c1d3
date added to LUP
2024-10-07 11:14:33
date last changed
2025-06-03 23:45:24
@article{e3c788b1-df2c-4501-bd4c-b465e232c1d3,
  abstract     = {{Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R (HuR) is a prominent RBP known to drive tumorigenesis with a pivotal role in CRC. In this review, we discuss the regulatory role of the HuR/miRNA axis in CRC. Interestingly, miRNAs can directly target HuR, altering its expression and activity. However, HuR can also stabilize or degrade miRNAs, forming complex feedback loops that either activate or block CRC-associated signaling pathways. Dysregulation of the HuR/miRNA axis contributes to CRC initiation and progression. Additionally, HuR-miRNA regulation by other small non-coding RNAs, circular RNA (circRNAs), or long-non-coding RNAs (lncRNAs) is also explored here. Understanding this HuR-miRNA interplay could reveal novel biomarkers with better diagnostic or prognostic accuracy.}},
  author       = {{Yadav, Vikas and Singh, Tejveer and Sharma, Deepika and Garg, Vivek Kumar and Chakraborty, Payel and Ghatak, Souvik and Satapathy, Shakti Ranjan}},
  issn         = {{2072-6694}},
  keywords     = {{microRNA; lncRNA; circular RNA; RNA-binding protein; HuR; colorectal cancer}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{18}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis}},
  url          = {{http://dx.doi.org/10.3390/cancers16183183}},
  doi          = {{10.3390/cancers16183183}},
  volume       = {{16}},
  year         = {{2024}},
}