Interaction of dietary and genetic factors influencing body iron status and risk of type 2 diabetes within the EPIC-InterAct study
(2018) In Diabetes Care 41(2). p.277-285- Abstract
OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and... (More)
OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (b = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (20.019 [20.043; 0.006]) or transferrin saturation (0.016 [20.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03). CONCLUSIONS We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
(Less)
- author
- organization
- publishing date
- 2018-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 41
- issue
- 2
- pages
- 277 - 285
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:29167213
- scopus:85041220590
- ISSN
- 0149-5992
- DOI
- 10.2337/dc17-1080
- language
- English
- LU publication?
- yes
- id
- e45f2fbc-593b-4133-93a3-c33227a5b398
- date added to LUP
- 2018-03-06 11:22:07
- date last changed
- 2024-09-16 18:10:03
@article{e45f2fbc-593b-4133-93a3-c33227a5b398, abstract = {{<p>OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (b = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (20.019 [20.043; 0.006]) or transferrin saturation (0.016 [20.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (P<sub>add</sub> = 0.16, P<sub>mult</sub> = 0.21) but did detect a trend toward a negative interaction in men (P<sub>add</sub> = 0.04, P<sub>mult</sub> = 0.03). CONCLUSIONS We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.</p>}}, author = {{Meidtner, Karina and Podmore, Clara and Kröger, Janine and Van Der Schouw, Yvonne T. and Bendinelli, Benedetta and Agnoli, Claudia and Arriola, Larraitz and Barricarte, Aurelio and Boeing, Heiner and Cross, Amanda J. and Dow, Courtney and Ekblom, Kim and Fagherazzi, Guy and Franks, Paul W. and Gunter, Marc J. and Huerta, José María and Jakszyn, Paula and Jenab, Mazda and Katzke, Verena A. and Key, Timothy J. and Khaw, Kay Tee and Kühn, Tilman and Kyrø, Cecilie and Mancini, Francesca Romana and Melander, Olle and Nilsson, Peter M. and Overvad, Kim and Palli, Domenico and Panico, Salvatore and Ramón Quirós, J. and Rodríguez-Barranco, Miguel and Sacerdote, Carlotta and Sluijs, Ivonne and Stepien, Magdalena and Tjonneland, Anne and Tumino, Rosario and Forouhi, Nita G. and Sharp, Stephen J. and Langenberg, Claudia and Schulze, Matthias B. and Riboli, Elio and Wareham, Nicholas J.}}, issn = {{0149-5992}}, language = {{eng}}, month = {{02}}, number = {{2}}, pages = {{277--285}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Interaction of dietary and genetic factors influencing body iron status and risk of type 2 diabetes within the EPIC-InterAct study}}, url = {{http://dx.doi.org/10.2337/dc17-1080}}, doi = {{10.2337/dc17-1080}}, volume = {{41}}, year = {{2018}}, }