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Gut response to pasteurized donor human milk in a porcine model of the premature infant

Socha-Banasiak, A. ; Pierzynowski, S. G. LU ; Szczurek, P. LU ; Woliński, J. LU ; Wesołowska, A. ; Czkwianianc, E. and Pierzynowska, K. LU orcid (2020) In Journal of Biological Regulators and Homeostatic Agents 34(6). p.2003-2015
Abstract

This study investigated the tolerance and safety of pasteurized donor human milk (PDHM) given either alone or together with commercially-used supplements in a porcine model of premature infants. A porcine model, mimicking human neonates at 30-32 weeks of gestational age, was used. The 7-day experiment was performed on 20 piglets. After birth, the piglets were infused with porcine immunoglobulins via the umbilical artery and surgically fitted with a stomach port. The piglets were then randomized into five groups and fed either PDHM, different variants of fortified PDHM or 'raw' human milk (RHM). Preterm piglets fed PDHM showed signs of gastrointestinal intolerance. Four piglets across the various PDHM-fed groups died, none of them were... (More)

This study investigated the tolerance and safety of pasteurized donor human milk (PDHM) given either alone or together with commercially-used supplements in a porcine model of premature infants. A porcine model, mimicking human neonates at 30-32 weeks of gestational age, was used. The 7-day experiment was performed on 20 piglets. After birth, the piglets were infused with porcine immunoglobulins via the umbilical artery and surgically fitted with a stomach port. The piglets were then randomized into five groups and fed either PDHM, different variants of fortified PDHM or 'raw' human milk (RHM). Preterm piglets fed PDHM showed signs of gastrointestinal intolerance. Four piglets across the various PDHM-fed groups died, none of them were from the group fed PDHM supplemented with long-chain polyunsaturated fatty acids (LC PUFA). In all groups fed PDHM, macroscopic features of enterocolitis were observed, however, these pathological gut changes were less manifested in piglets receiving PDHM supplemented with LC PUFA. The piglets fed RHM had no specific signs of gut damage. The poor tolerance to PDHM suggests changes in milk composition caused by the Holder pasteurization. The supplementation with LC PUFA probably improves tolerance to PDHM.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
milk fortification, milk pasteurization, preterm infants, preterm piglets
in
Journal of Biological Regulators and Homeostatic Agents
volume
34
issue
6
pages
13 pages
publisher
Biolife SAS
external identifiers
  • scopus:85099774188
  • pmid:33325224
ISSN
0393-974X
DOI
10.23812/20-272-A
language
English
LU publication?
yes
id
eddc4239-2c0f-415f-91ae-1b016fe029a9
date added to LUP
2021-02-05 09:09:29
date last changed
2025-01-11 05:01:26
@article{eddc4239-2c0f-415f-91ae-1b016fe029a9,
  abstract     = {{<p>This study investigated the tolerance and safety of pasteurized donor human milk (PDHM) given either alone or together with commercially-used supplements in a porcine model of premature infants. A porcine model, mimicking human neonates at 30-32 weeks of gestational age, was used. The 7-day experiment was performed on 20 piglets. After birth, the piglets were infused with porcine immunoglobulins via the umbilical artery and surgically fitted with a stomach port. The piglets were then randomized into five groups and fed either PDHM, different variants of fortified PDHM or 'raw' human milk (RHM). Preterm piglets fed PDHM showed signs of gastrointestinal intolerance. Four piglets across the various PDHM-fed groups died, none of them were from the group fed PDHM supplemented with long-chain polyunsaturated fatty acids (LC PUFA). In all groups fed PDHM, macroscopic features of enterocolitis were observed, however, these pathological gut changes were less manifested in piglets receiving PDHM supplemented with LC PUFA. The piglets fed RHM had no specific signs of gut damage. The poor tolerance to PDHM suggests changes in milk composition caused by the Holder pasteurization. The supplementation with LC PUFA probably improves tolerance to PDHM.</p>}},
  author       = {{Socha-Banasiak, A. and Pierzynowski, S. G. and Szczurek, P. and Woliński, J. and Wesołowska, A. and Czkwianianc, E. and Pierzynowska, K.}},
  issn         = {{0393-974X}},
  keywords     = {{milk fortification; milk pasteurization; preterm infants; preterm piglets}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2003--2015}},
  publisher    = {{Biolife SAS}},
  series       = {{Journal of Biological Regulators and Homeostatic Agents}},
  title        = {{Gut response to pasteurized donor human milk in a porcine model of the premature infant}},
  url          = {{http://dx.doi.org/10.23812/20-272-A}},
  doi          = {{10.23812/20-272-A}},
  volume       = {{34}},
  year         = {{2020}},
}