Quantitative trait loci mapping of functional traits in the german Holstein cattle population
(2003) In Journal of Dairy Science 86(1). p.360-368- Abstract
A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYSm, DYSd) and still-birth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were... (More)
A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYSm, DYSd) and still-birth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYSm on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Yps, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.
(Less)
- author
- publishing date
- 2003-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Functional traits, Holstein cattle, Quantitative trait loci
- in
- Journal of Dairy Science
- volume
- 86
- issue
- 1
- pages
- 9 pages
- publisher
- American Dairy Science Association
- external identifiers
-
- scopus:4043162145
- pmid:12613879
- ISSN
- 0022-0302
- DOI
- 10.3168/jds.S0022-0302(03)73614-5
- language
- English
- LU publication?
- no
- id
- eebc3e4a-ee52-468c-beff-5dd5bf55db2d
- date added to LUP
- 2018-10-10 13:38:45
- date last changed
- 2024-06-10 19:28:02
@article{eebc3e4a-ee52-468c-beff-5dd5bf55db2d, abstract = {{<p>A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYS<sub>m</sub>, DYS<sub>d</sub>) and still-birth (STI<sub>m</sub>, STI<sub>d</sub>) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90<sub>m</sub>, NR90<sub>p</sub>). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYS<sub>m</sub> on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Y<sub>ps</sub>, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.</p>}}, author = {{Kühn, Ch and Bennewitz, J. and Reinsch, N. and Xu, N. and Thomsen, H. and Looft, C. and Brockmann, G. A. and Schwerin, M. and Weimann, C. and Hiendleder, S. and Erhardt, G. and Medjugorac, I. and Förster, M. and Brenig, B. and Reinhardt, F. and Reents, R. and Russ, I. and Averdunk, G. and Blümel, J. and Kalm, E.}}, issn = {{0022-0302}}, keywords = {{Functional traits; Holstein cattle; Quantitative trait loci}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{360--368}}, publisher = {{American Dairy Science Association}}, series = {{Journal of Dairy Science}}, title = {{Quantitative trait loci mapping of functional traits in the german Holstein cattle population}}, url = {{http://dx.doi.org/10.3168/jds.S0022-0302(03)73614-5}}, doi = {{10.3168/jds.S0022-0302(03)73614-5}}, volume = {{86}}, year = {{2003}}, }