Tactile friction of topical creams and emulsions : Friction measurements on excised skin and VitroSkin® using ForceBoard™
Ali, A. ; Ringstad, L. ; Skedung, L. ; Falkman, P. ; Wahlgren, M. LU
and Engblom, J.
(2022)
In International Journal of Pharmaceutics
615.
- Abstract
Tactile perception can be investigated through ex vivo friction measurements using a so–called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfactant-based creams, and a particle-stabilized (Pickering) cream and investigate how the different substrates affect the results obtained. It was found that the difference in tactile friction between excised skin and VitroSkin® was small on untreated substrates. When topical creams were applied, the same trends were observed for both substrates,... (More)
Tactile perception can be investigated through ex vivo friction measurements using a so–called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfactant-based creams, and a particle-stabilized (Pickering) cream and investigate how the different substrates affect the results obtained. It was found that the difference in tactile friction between excised skin and VitroSkin® was small on untreated substrates. When topical creams were applied, the same trends were observed for both substrates, although the frictional variation over time relates to the difference in surface structure between the two substrates. The results also confirmed that there is a difference between starch-based Pickering formulations and surfactant-based creams after application, indicating that the latter is greasier than Pickering cream. It was also shown that the tactile friction of Pickering emulsions was consistently high even with high amounts of oil, indicating a non-greasy, and non-sticky formulation. The characteristics of starch-stabilized Pickering formulations make them promising candidates in the development of surfactant-free topical formulations with unique tactile properties.
(Less)
- author
- Ali, A.
; Ringstad, L.
; Skedung, L.
; Falkman, P.
; Wahlgren, M.
LU
and Engblom, J.
- organization
- publishing date
- 2022-03-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Excised skin, Force-Board™, Pickering emulsions, Surfactant-free formulations, Tactile friction, Topical creams, VitroSkin®
- in
- International Journal of Pharmaceutics
- volume
- 615
- article number
- 121502
- publisher
- Elsevier
- external identifiers
-
- scopus:85123703718
- pmid:35091002
- ISSN
- 0378-5173
- DOI
- 10.1016/j.ijpharm.2022.121502
- language
- English
- LU publication?
- yes
- id
- fc59e9b4-76df-4a85-b857-eb642d871504
- date added to LUP
- 2022-03-24 16:44:28
- date last changed
- 2024-07-11 13:50:39
@article{fc59e9b4-76df-4a85-b857-eb642d871504,
abstract = {{<p>Tactile perception can be investigated through ex vivo friction measurements using a so–called ForceBoard™, providing objective assessments and savings in time and money, compared to a subjective human panel. In this work we aim to compare excised skin versus VitroSkin® as model substrates for tactile friction measurements. A further aim is to detect possible differences between traditional surfactant-based creams, and a particle-stabilized (Pickering) cream and investigate how the different substrates affect the results obtained. It was found that the difference in tactile friction between excised skin and VitroSkin® was small on untreated substrates. When topical creams were applied, the same trends were observed for both substrates, although the frictional variation over time relates to the difference in surface structure between the two substrates. The results also confirmed that there is a difference between starch-based Pickering formulations and surfactant-based creams after application, indicating that the latter is greasier than Pickering cream. It was also shown that the tactile friction of Pickering emulsions was consistently high even with high amounts of oil, indicating a non-greasy, and non-sticky formulation. The characteristics of starch-stabilized Pickering formulations make them promising candidates in the development of surfactant-free topical formulations with unique tactile properties.</p>}},
author = {{Ali, A. and Ringstad, L. and Skedung, L. and Falkman, P. and Wahlgren, M. and Engblom, J.}},
issn = {{0378-5173}},
keywords = {{Excised skin; Force-Board™; Pickering emulsions; Surfactant-free formulations; Tactile friction; Topical creams; VitroSkin®}},
language = {{eng}},
month = {{03}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{Tactile friction of topical creams and emulsions : Friction measurements on excised skin and VitroSkin® using ForceBoard™}},
url = {{http://dx.doi.org/10.1016/j.ijpharm.2022.121502}},
doi = {{10.1016/j.ijpharm.2022.121502}},
volume = {{615}},
year = {{2022}},
}