Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

GABA and GABA-transporter (GAT-1) immunoreactivities in the retina of the salmon (Salmo salar L.)

Ekström, Peter LU and Anzelius, Marie LU (1998) In Brain Research 812(1-2). p.179-185
Abstract

Putative GABAergic elements in the retina of the Atlantic salmon have been identified by immunohistochemistry, utilising polyclonal antisera against γ-aminobutyric acid (GABA) and the GABA transporter GAT-1. Cell types immunoreactive (ir) for GABA comprise horizontal cells, amacrine cells, displaced amacrine cells in the ganglion cell layer, displaced amacrine cells in the inner plexiform layer (interstitial cells), and Muller cells. In addition, a GABA-immunonegative type of interstitial cell was also identified. In the inner plexiform layer, GABAir fibres were organised in sublayers that were strikingly similar to the sublayering of GAT-1ir fibres. GAT-lir cell bodies comprise amacrine cells and displaced amacrine cells that may... (More)

Putative GABAergic elements in the retina of the Atlantic salmon have been identified by immunohistochemistry, utilising polyclonal antisera against γ-aminobutyric acid (GABA) and the GABA transporter GAT-1. Cell types immunoreactive (ir) for GABA comprise horizontal cells, amacrine cells, displaced amacrine cells in the ganglion cell layer, displaced amacrine cells in the inner plexiform layer (interstitial cells), and Muller cells. In addition, a GABA-immunonegative type of interstitial cell was also identified. In the inner plexiform layer, GABAir fibres were organised in sublayers that were strikingly similar to the sublayering of GAT-1ir fibres. GAT-lir cell bodies comprise amacrine cells and displaced amacrine cells that may represent a subpopulation of the GABAir ones. In view of the very similar sublayering of GABAir and GAT-ir fibres in the IPL we suggest that a similar type of GABA transporter, that can be recognised with antibodies against rat GAT-1, is present at least in the dendrites of all GABAir amacrine cells but is not expressed in the cell bodies of all GABAir cells.

(Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amacrine cell, Horizontal cell, Immunohistochemistry, Muller glia, Teleost
in
Brain Research
volume
812
issue
1-2
pages
179 - 185
publisher
Elsevier
external identifiers
  • scopus:0032561725
  • pmid:9813314
ISSN
0006-8993
DOI
10.1016/S0006-8993(98)00994-9
language
English
LU publication?
yes
id
ffa935ca-4c28-41ce-8569-346b1c01a6be
date added to LUP
2019-10-02 15:10:31
date last changed
2024-03-04 03:46:54
@article{ffa935ca-4c28-41ce-8569-346b1c01a6be,
  abstract     = {{<p>Putative GABAergic elements in the retina of the Atlantic salmon have been identified by immunohistochemistry, utilising polyclonal antisera against γ-aminobutyric acid (GABA) and the GABA transporter GAT-1. Cell types immunoreactive (ir) for GABA comprise horizontal cells, amacrine cells, displaced amacrine cells in the ganglion cell layer, displaced amacrine cells in the inner plexiform layer (interstitial cells), and Muller cells. In addition, a GABA-immunonegative type of interstitial cell was also identified. In the inner plexiform layer, GABAir fibres were organised in sublayers that were strikingly similar to the sublayering of GAT-1ir fibres. GAT-lir cell bodies comprise amacrine cells and displaced amacrine cells that may represent a subpopulation of the GABAir ones. In view of the very similar sublayering of GABAir and GAT-ir fibres in the IPL we suggest that a similar type of GABA transporter, that can be recognised with antibodies against rat GAT-1, is present at least in the dendrites of all GABAir amacrine cells but is not expressed in the cell bodies of all GABAir cells.</p>}},
  author       = {{Ekström, Peter and Anzelius, Marie}},
  issn         = {{0006-8993}},
  keywords     = {{Amacrine cell; Horizontal cell; Immunohistochemistry; Muller glia; Teleost}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{1-2}},
  pages        = {{179--185}},
  publisher    = {{Elsevier}},
  series       = {{Brain Research}},
  title        = {{GABA and GABA-transporter (GAT-1) immunoreactivities in the retina of the salmon (Salmo salar L.)}},
  url          = {{http://dx.doi.org/10.1016/S0006-8993(98)00994-9}},
  doi          = {{10.1016/S0006-8993(98)00994-9}},
  volume       = {{812}},
  year         = {{1998}},
}