Stem Cells to Red Blood Cells

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2022
Mark Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector
Liu, Yang ^LU ; Dahl, Maria ^LU ; Debnath, Shubhranshu ^LU ; Rothe, Michael ; Smith, Emma ^LU ; Tan Grahn, Hooi Min ^LU ; Warsi, Sarah ^LU ; Chen, Jun ^LU ; Flygare, Johan ^LU and Schambach, Axel , et al. (2022) In Haematologica 107(2). p.446-456
- Contribution to journal › Article
2021
Mark Decreased PGC1beta expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit
Sen, Taha ^LU ; Chen, Jun ^LU and Singbrant, Sofie ^LU (2021) In Scientific Reports 11(1). p.1-14
- Contribution to journal › Article
Mark Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan anemia corrects the disease phenotype
Dahl, Maria ^LU ; Warsi, Sarah ^LU ; Liu, Yang ^LU ; Debnath, Shubhranshu ^LU ; Billing, Matilda ^LU ; Siva, Kavitha ^LU ; Flygare, Johan ^LU and Karlsson, Stefan ^LU (2021) In Experimental Hematology 99. p.2-53
- Contribution to journal › Article
Mark The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond–Blackfan anemia by targeting Nemo-like kinase
Wilkes, Mark C. ; Jung, Kevin ; Lee, Britney E. ; Saxena, Mallika ; Sathianathen, Ryan S. ; Mercado, Jacqueline D. ; Perez, Cristina ; Flygare, Johan ^LU ; Narla, Anupama and Glader, Bertil , et al. (2021) In Journal of Biological Chemistry 297(3).
- Contribution to journal › Article
Mark Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity
Mattebo, Alexander ^LU ; Sen, Taha ^LU ; Jassinskaja, Maria ^LU ; Pimková, Kristýna ^LU ; Prieto González-Albo, Isabel ; Alattar, Abdul Ghani ^LU ; Ramakrishnan, Ramprasad ^LU ; Lang, Stefan ^LU ; Järås, Marcus ^LU and Hansson, Jenny ^LU , et al. (2021) In Scientific Reports 11(1).
- Contribution to journal › Article
Mark Human radical scavenger α1-microglobulin protects against hemolysis in vitro and α1-microglobulin knockout mice exhibit a macrocytic anemia phenotype
Kristiansson, Amanda ^LU ; Bergwik, Jesper ^LU ; Alattar, Abdul Ghani ^LU ; Flygare, Johan ^LU ; Gram, Magnus ^LU ; Hansson, Stefan R ^LU ; Olsson, Martin L ^LU ; Storry, Jill R ^LU ; Allhorn, Maria ^LU and Åkerström, Bo ^LU (2021) In Free Radical Biology & Medicine 162.
- Contribution to journal › Article
2020
Mark Gene editing of CD34+ progenitor cells from single blood donor waste bags to create cultured early erythroid cells for study of blood group knock-outs
Alattar, AG ^LU ; Bäckström, A ^LU ; Flygare, J ^LU ; Storry, J ^LU ; Larsson, J ^LU and Olsson, ML ^LU (2020) The 36th International ISBT Congress, Virtual meeting In Vox Sanguinis 115(Suppl. s1). p.363-363
- Contribution to journal › Published meeting abstract
Mark The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions
Kristiansson, Amanda ^LU ; Gram, Magnus ^LU ; Flygare, Johan ^LU ; Hansson, Stefan R ^LU ; Åkerström, Bo ^LU and Storry, Jill R ^LU (2020) In International Journal of Molecular Sciences 21(19). p.1-21
- Contribution to journal › Scientific review
Mark Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output
Singbrant, Sofie ^LU ; Mattebo, Alexander ^LU ; Sigvardsson, Mikael ^LU ; Strid, Tobias ^LU and Flygare, Johan ^LU (2020) In Haematologica 105(11). p.2561-2571
- Contribution to journal › Article
Mark Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia
Taylor, Alison M. ; Macari, Elizabeth R. ; Chan, Iris T. ; Blair, Megan C. ; Doulatov, Sergei ; Vo, Linda T. ; Raiser, David M. ; Siva, Kavitha ^LU ; Basak, Anindita and Pirouz, Mehdi , et al. (2020) In Science Translational Medicine 12(566).
- Contribution to journal › Article