Jun Chen

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2022
Mark Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector
Liu, Yang ^LU ; Dahl, Maria ^LU ; Debnath, Shubhranshu ^LU ; Rothe, Michael ; Smith, Emma ^LU ; Tan Grahn, Hooi Min ^LU ; Warsi, Sarah ^LU ; Chen, Jun ^LU ; Flygare, Johan ^LU and Schambach, Axel , et al. (2022) In Haematologica 107(2). p.446-456
- Contribution to journal › Article
Mark Targeting elevated heme levels to treat a mouse model for Diamond-Blackfan Anemia
Sjögren, Sara E. ^LU ; Chen, Jun ^LU ; Mattebo, Alexander ^LU ; Alattar, Abdul G. ^LU ; Karlsson, Helena ^LU ; Siva, Kavitha ^LU ; Soneji, Shamit ^LU ; Tedgård, Ulf ^LU ; Chen, Jane Jane and Gram, Magnus ^LU , et al. (2022) In Experimental Hematology 105. p.50-61
- Contribution to journal › Article
2021
Mark Decreased PGC1beta expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit
Sen, Taha ^LU ; Chen, Jun ^LU and Singbrant, Sofie ^LU (2021) In Scientific Reports 11(1). p.1-14
- Contribution to journal › Article
2020
Mark Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171
Subramaniam, Agatheeswaran ^LU ; Zemaitis, Kristijonas ^LU ; Safaee Talkhoncheh, Mehrnaz ^LU ; Yudovich, David ^LU ; Bäckström, Alexandra ^LU ; Debnath, Shubhranshu ^LU ; Chen, Jun ^LU ; Jain, Mayur Vilas ^LU ; Galeev, Roman ^LU and Gaetani, Massimiliano , et al. (2020) In Blood 136(19). p.2151-2161
- Contribution to journal › Article
Mark Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
Wilkes, M. C. ; Siva, K. ^LU ; Chen, J. ^LU ; Varetti, G. ; Youn, M. Y. ; Chae, H. ; Ek, F. ^LU ; Olsson, R. ^LU ; Lundbäck, T. and Dever, D. P. , et al. (2020) In Nature Communications 11(1).
- Contribution to journal › Article
Mark Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond–Blackfan anemia through induction of miR-26a
Wilkes, Mark C. ; Siva, Kavitha ^LU ; Varetti, Gianluca ; Mercado, Jacqueline ; Wentworth, Ethan P. ; Perez, Cristina A. ; Saxena, Mallika ; Kam, Sharon ; Kapur, Simryn and Chen, Jun ^LU , et al. (2020) In Experimental Hematology 91. p.65-77
- Contribution to journal › Article
2019
Mark A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia
Siva, Kavitha ^LU ; Ek, Fredrik ^LU ; Chen, Jun ^LU ; Ghani Alattar, Abdul ^LU ; Sigmundsson, Kristmundur ; Olsson, Roger ^LU ; Wlodarski, Marcin ; Lundbäck, Thomas and Flygare, Johan ^LU (2019) In SLAS Discovery 24(3). p.304-313
- Contribution to journal › Article
2018
Mark Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs
Chen, Jun ^LU ; Siva, Kavitha ^LU ; Rzymski, Tomasz ; Johansson, Lars ; Lundbäck, Thomas ; Nunez villacis, Lorena ; Ek, Fredrik ^LU ; Wang, Bingrui ; George, Amee J and Wan, Yang , et al. (2018) In Blood 132(Supplement 1). p.753-753
- Contribution to journal › Published meeting abstract
2017
Mark Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia
Debnath, Shubhranshu ^LU ; Jaako, Pekka ^LU ; Siva, Kavitha ^LU ; Rothe, Michael ; Chen, Jun ^LU ; Dahl, Maria ^LU ; Gaspar, H. Bobby ; Flygare, Johan ^LU ; Schambach, Axel and Karlsson, Stefan ^LU (2017) In Molecular Therapy 25(8). p.1805-1814
- Contribution to journal › Article
Mark Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration
Komorowska, Karolina ^LU ; Doyle, Alexander ^LU ; Wahlestedt, Martin ^LU ; Subramaniam, Agatheeswaran ^LU ; Debnath, Shubhranshu ^LU ; Chen, Jun ^LU ; Soneji, Shamit ^LU ; Van Handel, Ben ; Mikkola, Hanna K.A. and Miharada, Kenichi ^LU , et al. (2017) In Cell Reports 21(12). p.3514-3523
- Contribution to journal › Article

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