Emma Scaletti (Former)

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2022
Mark Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas, N. ; Scaletti, E.R. ^LU ; Stenmark, P. ^LU and Helleday, T. (2022) In Nature Cancer 3(2). p.156-172
- Contribution to journal › Article
Mark Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus
Rehling, Daniel ; Scaletti, Emma Rose ^LU ; Rozman Grinberg, Inna ; Lundin, Daniel ; Sahlin, Margareta ; Hofer, Anders ; Sjöberg, Britt-Marie and Stenmark, Pål ^LU (2022) In Biochemistry 61(2). p.92-106
- Contribution to journal › Article
Mark Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
Michel, M. ; Scaletti, E.R. ^LU ; Stenmark, P. ^LU and Helleday, T. (2022) In Science 376(6600). p.1471-1476
- Contribution to journal › Article
2021
Mark Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling, Daniel ; Zhang, Si Min ; Jemth, Ann-Sofie ; Koolmeister, Tobias ; Throup, Adam ; Wallner, Olov ; Scaletti, Emma ^LU ; Moriyama, Takaya ; Nishii, Rina and Davies, Jonathan , et al. (2021) In The Journal of biological chemistry 296.
- Contribution to journal › Article
2020
Mark Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
Suiter, Chase C ; Moriyama, Takaya ; Matreyek, Kenneth A ; Yang, Wentao ; Scaletti, Emma Rose ^LU ; Nishii, Rina ; Yang, Wenjian ; Hoshitsuki, Keito ; Singh, Minu and Trehan, Amita , et al. (2020) In Proceedings of the National Academy of Sciences of the United States of America 117(10). p.5394-5401
- Contribution to journal › Article
Mark MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
Scaletti, Emma Rose ^LU ; Vallin, Karl S ; Bräutigam, Lars ; Sarno, Antonio ; Berglund, Ulrika Warpman ; Helleday, Thomas ; Stenmark, Pål ^LU and Jemth, Ann-Sofie (2020) In Journal of Biological Chemistry 295(15). p.4761-4772
- Contribution to journal › Article
Mark The first structure of an active mammalian dCTPase and its complexes with substrate analogues and products
Scaletti, Emma ^LU ; Claesson, Magnus ; Helleday, Thomas ; Jemth, Ann-Sofie and Stenmark, Pål ^LU (2020) In Journal of Molecular Biology 432(4). p.1126-1142
- Contribution to journal › Article
2019
Mark Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
Jemth, Ann Sofie ; Scaletti, Emma ^LU ; Carter, Megan ; Helleday, Thomas and Stenmark, Pål ^LU (2019) In Biochemistry 58(7). p.887-899
- Contribution to journal › Article
Mark Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti, Emma ^LU ; Jemth, Ann-Sofie ; Helleday, Thomas and Stenmark, Pål ^LU (2019) In FEBS Letters 593(14). p.1863-1873
- Contribution to journal › Article