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2021
Mark Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling, Daniel ; Zhang, Si Min ; Jemth, Ann-Sofie ; Koolmeister, Tobias ; Throup, Adam ; Wallner, Olov ; Scaletti, Emma ^LU ; Moriyama, Takaya ; Nishii, Rina and Davies, Jonathan , et al. (2021) In The Journal of biological chemistry 296.
- Contribution to journal › Article
Mark NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang, Si Min ; Rehling, Daniel ; Jemth, Ann-Sofie ; Throup, Adam ; Landázuri, Natalia ; Almlöf, Ingrid ; Göttmann, Mona ; Valerie, Nicholas C K ; Borhade, Sanjay R and Wakchaure, Prasad , et al. (2021) In Cell Chemical Biology 28(12). p.6-1702
- Contribution to journal › Article
2020
Mark The first structure of an active mammalian dCTPase and its complexes with substrate analogues and products
Scaletti, Emma ^LU ; Claesson, Magnus ; Helleday, Thomas ; Jemth, Ann-Sofie and Stenmark, Pål ^LU (2020) In Journal of Molecular Biology 432(4). p.1126-1142
- Contribution to journal › Article
Mark Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
Škerlová, Jana ; Unterlass, Judith ; Göttmann, Mona ; Marttila, Petra ; Homan, Evert ; Helleday, Thomas ; Jemth, Ann-Sofie and Stenmark, Pål ^LU (2020) In Journal of Biological Chemistry 295(33). p.11656-11668
- Contribution to journal › Article
Mark MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
Scaletti, Emma Rose ^LU ; Vallin, Karl S ; Bräutigam, Lars ; Sarno, Antonio ; Berglund, Ulrika Warpman ; Helleday, Thomas ; Stenmark, Pål ^LU and Jemth, Ann-Sofie (2020) In Journal of Biological Chemistry 295(15). p.4761-4772
- Contribution to journal › Article
Mark Development of a chemical probe against NUDT15
Zhang, Si Min ; Desroses, Matthieu ; Hagenkort, Anna ; Valerie, Nicholas C K ; Rehling, Daniel ; Carter, Megan ; Wallner, Olov ; Koolmeister, Tobias ; Throup, Adam and Jemth, Ann-Sofie , et al. (2020) In Nature Chemical Biology 16(10). p.1120-1128
- Contribution to journal › Article
Mark Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes, Torkild ; Benítez-Buelga, Carlos ; Cázares-Körner, Armando ; Sanjiv, Kumar ; Hanna, Bishoy M F ; Mortusewicz, Oliver ; Rajagopal, Varshni ; Albers, Julian J ; Hagey, Daniel W and Bekkhus, Tove , et al. (2020) In Nucleic Acids Research
- Contribution to journal › Article
2019
Mark Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti, Emma ^LU ; Jemth, Ann-Sofie ; Helleday, Thomas and Stenmark, Pål ^LU (2019) In FEBS Letters 593(14). p.1863-1873
- Contribution to journal › Article
Mark Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
Jemth, Ann Sofie ; Scaletti, Emma ^LU ; Carter, Megan ; Helleday, Thomas and Stenmark, Pål ^LU (2019) In Biochemistry 58(7). p.887-899
- Contribution to journal › Article
2018
Mark Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
Narwal, Mohit ; Jemth, Ann-Sofie ; Gustafsson, Robert ; Almlöf, Ingrid ; Warpman Berglund, Ulrika ; Helleday, Thomas and Stenmark, Pål ^LU (2018) In Biochemistry 57(5). p.593-603
- Contribution to journal › Article

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