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- 2021
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Mark
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
(
- Contribution to journal › Article
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Mark
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
(
- Contribution to journal › Article
- 2020
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Mark
The first structure of an active mammalian dCTPase and its complexes with substrate analogues and products
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- Contribution to journal › Article
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Mark
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
(
- Contribution to journal › Article
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Mark
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
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- Contribution to journal › Article
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Mark
Development of a chemical probe against NUDT15
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- Contribution to journal › Article
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Mark
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
2020) In Nucleic Acids Research(
- Contribution to journal › Article
- 2019
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Mark
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
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- Contribution to journal › Article
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Mark
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
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- Contribution to journal › Article
- 2018
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Mark
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
(
- Contribution to journal › Article
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Mark
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
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- Contribution to journal › Article
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Mark
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
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- Contribution to journal › Article
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Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis
(
- Contribution to journal › Article
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Mark
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
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- Contribution to journal › Article
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Mark
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
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- Contribution to journal › Article
- 2017
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Mark
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
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- Contribution to journal › Article
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Mark
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
(
- Contribution to journal › Article
- 2016
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Mark
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
(
- Contribution to journal › Article