Peter Ellmark

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2023
Mark ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1
Enell Smith, Karin ; Fritzell, Sara ; Nilsson, Anneli ; Barchan, Karin ; Rosén, Anna ; Schultz, Lena ; Varas, Laura ; Säll, Anna ; Rose, Nadia and Håkansson, Maria , et al. (2023) In Cancer Immunology, Immunotherapy 72(12). p.4145-4159
- Contribution to journal › Article
Mark Early Pharmacodynamic Changes Measured Using RNA Sequencing of Peripheral Blood from Patients in a Phase I Study with Mitazalimab, a Potent CD40 Agonistic Monoclonal Antibody
Andersson, Hampus ^LU ; Sobti, Aastha ^LU ; Jimenez, David Gomez ^LU ; de Coaña, Yago Pico ; Ambarkhane, Sumeet Vijay ; Hägerbrand, Karin ^LU ; Smith, Karin Enell ; Lindstedt, Malin ^LU and Ellmark, Peter ^LU (2023) In Cells 12(19).
- Contribution to journal › Article
2022
Mark Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies
Hägerbrand, Karin ^LU ; Varas, Laura ^LU ; Deronic, Adnan ^LU ; Nyesiga, Barnabas ; Sundstedt, Anette ^LU ; Ljung, Lill ; Sakellariou, Christina ^LU ; Werchau, Doreen ; Thagesson, Mia and Gomez Jimenez, David ^LU , et al. (2022) In Journal for ImmunoTherapy of Cancer 10(11).
- Contribution to journal › Article
Mark Transcriptional profiling demonstrates altered characteristics of CD8 + cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia
Abolhalaj, Milad ^LU ; Sincic, Viktor ^LU ; Lilljebjörn, Henrik ^LU ; Sandén, Carl ^LU ; Aab, Alar ^LU ; Hägerbrand, Karin ^LU ; Ellmark, Peter ^LU ; Borrebaeck, Carl ^LU ; Fioretos, Thoas ^LU and Lundberg, Kristina ^LU (2022) In Cancer Medicine 11(15). p.3023-3032
- Contribution to journal › Article
2021
Mark CD137 (4-1BB) costimulation of CD8⁺ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
Otano, Itziar ; Azpilikueta, Arantza ; Glez-Vaz, Javier ; Alvarez, Maite ; Medina-Echeverz, José ; Cortés-Domínguez, Ivan ; Ortiz-de-Solorzano, Carlos ; Ellmark, Peter ^LU ; Fritzell, Sara ^LU and Hernandez-Hoyos, Gabriela , et al. (2021) In Nature Communications 12(1).
- Contribution to journal › Article
Mark Rationale and clinical development of CD40 agonistic antibodies for cancer immunotherapy
Enell Smith, Karin ^LU ; Deronic, Adnan ^LU ; Hägerbrand, Karin ^LU ; Norlén, Per ^LU and Ellmark, Peter ^LU (2021) In Expert Opinion on Biological Therapy 21(12). p.1635-1646
- Contribution to journal › Scientific review
Mark The human anti-CD40 agonist antibody mitazalimab (ADC-1013; JNJ-64457107) activates antigen-presenting cells, improves expansion of antigen-specific T cells, and enhances anti-tumor efficacy of a model cancer vaccine in vivo
Deronic, Adnan ^LU ; Nilsson, Anneli ; Thagesson, Mia ; Werchau, Doreen ; Enell Smith, Karin ^LU and Ellmark, Peter ^LU (2021) In Cancer Immunology, Immunotherapy 70(12). p.3629-3642
- Contribution to journal › Article
2020
Mark Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer.
Sincic, Viktor ^LU ; Abolhalaj, Milad ^LU ; Lilljebjörn, Henrik ^LU ; Aab, Alar ^LU ; Hägerbrand, Karin ^LU ; Ellmark, Peter ^LU ; Fioretos, Thoas ^LU ; Borrebaeck, Carl ^LU ; Liedberg, Fredrik ^LU and Lundberg, Kristina ^LU (2020) The Society for Immunotherapy of Cancer's (SITC) 35th annual meeting In Journal for ImmunoTherapy of Cancer 8(Suppl. 3).
- Contribution to journal › Published meeting abstract
Mark Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
Georganaki, Maria ; Ramachandran, Mohanraj ; Tuit, Sander ; Núñez, Nicolás Gonzalo ; Karampatzakis, Alexandros ; Fotaki, Grammatiki ; van Hooren, Luuk ; Huang, Hua ; Lugano, Roberta and Ulas, Thomas , et al. (2020) In OncoImmunology 9(1).
- Contribution to journal › Article
2019
Mark First-in-human study with intratumoral administration of a CD40 agonistic antibody, ADC-1013, in advanced solid malignancies
Irenaeus, Sandra M.M. ; Nielsen, Dorte ; Ellmark, Peter ^LU ; Yachnin, Jeffrey ; Deronic, Adnan ^LU ; Nilsson, Anneli ^LU ; Norlén, Per ^LU ; Veitonmäki, Niina ; Wennersten, Camilla S. and Ullenhag, Gustav J. (2019) In International Journal of Cancer 145(5). p.1189-1199
- Contribution to journal › Article