Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging : Assessment of sensitivity and resolution to detect alterations in tissue stiffness
(2019) 2019 IEEE International Ultrasonics Symposium, IUS 2019 In IEEE International Ultrasonics Symposium, IUS 2019-October. p.1077-1080- Abstract
A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue... (More)
A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.
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- author
- Sjostrand, Sandra LU ; Evertsson, Maria LU ; Thring, Claire ; Bacou, Marion ; Farrington, Susan ; Moug, Susan ; Moran, Carmel ; Jansson, Tomas LU and Mulvana, Helen
- organization
- publishing date
- 2019-12-09
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- colorectal cancer, contrast-enhanced magneto-motive ultrasound, elastography, magnetic microbubbles, SPION
- host publication
- 2019 IEEE International Ultrasonics Symposium, IUS 2019
- series title
- IEEE International Ultrasonics Symposium, IUS
- volume
- 2019-October
- article number
- 8926058
- pages
- 4 pages
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- 2019 IEEE International Ultrasonics Symposium, IUS 2019
- conference location
- Glasgow, United Kingdom
- conference dates
- 2019-10-06 - 2019-10-09
- external identifiers
-
- scopus:85077611352
- ISSN
- 1948-5719
- 1948-5727
- ISBN
- 9781728145969
- 978-1-7281-4597-6
- DOI
- 10.1109/ULTSYM.2019.8926058
- language
- English
- LU publication?
- yes
- id
- 05035d22-47a5-43e1-b538-0942d63549b3
- date added to LUP
- 2020-01-27 14:04:21
- date last changed
- 2024-03-20 03:21:37
@inproceedings{05035d22-47a5-43e1-b538-0942d63549b3, abstract = {{<p>A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.</p>}}, author = {{Sjostrand, Sandra and Evertsson, Maria and Thring, Claire and Bacou, Marion and Farrington, Susan and Moug, Susan and Moran, Carmel and Jansson, Tomas and Mulvana, Helen}}, booktitle = {{2019 IEEE International Ultrasonics Symposium, IUS 2019}}, isbn = {{9781728145969}}, issn = {{1948-5719}}, keywords = {{colorectal cancer; contrast-enhanced magneto-motive ultrasound; elastography; magnetic microbubbles; SPION}}, language = {{eng}}, month = {{12}}, pages = {{1077--1080}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, series = {{IEEE International Ultrasonics Symposium, IUS}}, title = {{Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging : Assessment of sensitivity and resolution to detect alterations in tissue stiffness}}, url = {{http://dx.doi.org/10.1109/ULTSYM.2019.8926058}}, doi = {{10.1109/ULTSYM.2019.8926058}}, volume = {{2019-October}}, year = {{2019}}, }