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Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging : Assessment of sensitivity and resolution to detect alterations in tissue stiffness

Sjostrand, Sandra LU ; Evertsson, Maria LU ; Thring, Claire ; Bacou, Marion ; Farrington, Susan ; Moug, Susan ; Moran, Carmel ; Jansson, Tomas LU and Mulvana, Helen (2019) 2019 IEEE International Ultrasonics Symposium, IUS 2019 In IEEE International Ultrasonics Symposium, IUS 2019-October. p.1077-1080
Abstract

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue... (More)

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
colorectal cancer, contrast-enhanced magneto-motive ultrasound, elastography, magnetic microbubbles, SPION
host publication
2019 IEEE International Ultrasonics Symposium, IUS 2019
series title
IEEE International Ultrasonics Symposium, IUS
volume
2019-October
article number
8926058
pages
4 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
2019 IEEE International Ultrasonics Symposium, IUS 2019
conference location
Glasgow, United Kingdom
conference dates
2019-10-06 - 2019-10-09
external identifiers
  • scopus:85077611352
ISSN
1948-5719
1948-5727
ISBN
9781728145969
978-1-7281-4597-6
DOI
10.1109/ULTSYM.2019.8926058
language
English
LU publication?
yes
id
05035d22-47a5-43e1-b538-0942d63549b3
date added to LUP
2020-01-27 14:04:21
date last changed
2024-03-20 03:21:37
@inproceedings{05035d22-47a5-43e1-b538-0942d63549b3,
  abstract     = {{<p>A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.</p>}},
  author       = {{Sjostrand, Sandra and Evertsson, Maria and Thring, Claire and Bacou, Marion and Farrington, Susan and Moug, Susan and Moran, Carmel and Jansson, Tomas and Mulvana, Helen}},
  booktitle    = {{2019 IEEE International Ultrasonics Symposium, IUS 2019}},
  isbn         = {{9781728145969}},
  issn         = {{1948-5719}},
  keywords     = {{colorectal cancer; contrast-enhanced magneto-motive ultrasound; elastography; magnetic microbubbles; SPION}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{1077--1080}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{IEEE International Ultrasonics Symposium, IUS}},
  title        = {{Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging : Assessment of sensitivity and resolution to detect alterations in tissue stiffness}},
  url          = {{http://dx.doi.org/10.1109/ULTSYM.2019.8926058}},
  doi          = {{10.1109/ULTSYM.2019.8926058}},
  volume       = {{2019-October}},
  year         = {{2019}},
}