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Detection of hepatic metastases in colorectal cancer : A prospective study of laboratory and imaging methods

Ohlsson, B. LU ; Tranberg, K. G. LU ; Lundstedt, C. LU ; Ekberg, H. LU and Hederstrom, E. (1993) In European Journal of Surgery, Acta Chirurgica 159(5). p.275-281
Abstract

Objective: To assess and compare the accuracy of imaging methods (ultrasonography (US), computed tomography (CT), angiography, arterially enhanced CT with computed tomographic arterial portography (CTA)), biochemical analyses, and surgical assessment during the operation, in detecting the presence or absence of hepatic metastases in patients with colorectal cancer. Design: Open study. Setting: University of Lund, Sweden. Subjects: 71 consecutive patients without clinical evidence of liver metastases at the time of the operation for removal of the primary tumour. Interventions: Regular biochemical tests for five to seven years, and CT and US one year after operation in all patients without confirmed metastases. Main outcome measures:... (More)

Objective: To assess and compare the accuracy of imaging methods (ultrasonography (US), computed tomography (CT), angiography, arterially enhanced CT with computed tomographic arterial portography (CTA)), biochemical analyses, and surgical assessment during the operation, in detecting the presence or absence of hepatic metastases in patients with colorectal cancer. Design: Open study. Setting: University of Lund, Sweden. Subjects: 71 consecutive patients without clinical evidence of liver metastases at the time of the operation for removal of the primary tumour. Interventions: Regular biochemical tests for five to seven years, and CT and US one year after operation in all patients without confirmed metastases. Main outcome measures: Presence or absence of hepatic metastases. Results: Accuracy of surgical assessment, angiography, US, CT and CTA was 90, 77, 80, 82 and 83%, respectively, and corresponding predictive values of a negative test were 87, 75, 77, 80 and 84%. Measurement of bilirubin concentration and hepatic enzyme activities were not helpful, and that of carcinoembryonic antigen had an accuracy of only 70%. Accuracy and predictive values were not improved by combining tests. Conclusion: The accuracy of US, CT or CTA was not good enough to merrit routine use before operations for colorectal cancer. They are potentially valuable for monitoring progress at follow up, but this remains to be confirmed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Carcinoembryonic antigen, Colorectal cancer, Imaging methods, Liver function tests, Liver metastases
in
European Journal of Surgery, Acta Chirurgica
volume
159
issue
5
pages
7 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:0027218264
  • pmid:8103361
ISSN
1102-4151
language
English
LU publication?
yes
id
0550682d-67c0-4320-912c-7a7c451b6e93
date added to LUP
2019-06-15 17:20:17
date last changed
2020-01-13 02:01:42
@article{0550682d-67c0-4320-912c-7a7c451b6e93,
  abstract     = {<p>Objective: To assess and compare the accuracy of imaging methods (ultrasonography (US), computed tomography (CT), angiography, arterially enhanced CT with computed tomographic arterial portography (CTA)), biochemical analyses, and surgical assessment during the operation, in detecting the presence or absence of hepatic metastases in patients with colorectal cancer. Design: Open study. Setting: University of Lund, Sweden. Subjects: 71 consecutive patients without clinical evidence of liver metastases at the time of the operation for removal of the primary tumour. Interventions: Regular biochemical tests for five to seven years, and CT and US one year after operation in all patients without confirmed metastases. Main outcome measures: Presence or absence of hepatic metastases. Results: Accuracy of surgical assessment, angiography, US, CT and CTA was 90, 77, 80, 82 and 83%, respectively, and corresponding predictive values of a negative test were 87, 75, 77, 80 and 84%. Measurement of bilirubin concentration and hepatic enzyme activities were not helpful, and that of carcinoembryonic antigen had an accuracy of only 70%. Accuracy and predictive values were not improved by combining tests. Conclusion: The accuracy of US, CT or CTA was not good enough to merrit routine use before operations for colorectal cancer. They are potentially valuable for monitoring progress at follow up, but this remains to be confirmed.</p>},
  author       = {Ohlsson, B. and Tranberg, K. G. and Lundstedt, C. and Ekberg, H. and Hederstrom, E.},
  issn         = {1102-4151},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {275--281},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Surgery, Acta Chirurgica},
  title        = {Detection of hepatic metastases in colorectal cancer : A prospective study of laboratory and imaging methods},
  volume       = {159},
  year         = {1993},
}