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Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets

Alhamimi, Said LU ; HEYMAN, LOVISA LU ; Plaza, Merichel LU ; Turner, Charlotta LU ; Berger, Karin LU and Spégel, Peter LU (2017) In Molecular Nutrition and Food Research2004-01-01+01:00 61(3).
Abstract

Scope: Lingonberries have been shown to reduce the detrimental effects of high-fat diet (HFD) on weight gain, plasma glucose, and inflammation. However, the extent of effects was recently shown to vary between different batches of berries. Here, we examine the metabolic response to two independent batches of lingonberries. Methods and results: Alterations in the phenotype and circulating metabolome elicited by three matched HFDs, two of which containing lingonberries (L1D and L2D) from different sources, were investigated. Glycemia was improved only in mice fed L1D, whereas liver function was improved and inflammation reduced in mice fed both L1D and L2D, compared to mice fed HFD. The unique improvement in glycemia elicited by L1D was... (More)

Scope: Lingonberries have been shown to reduce the detrimental effects of high-fat diet (HFD) on weight gain, plasma glucose, and inflammation. However, the extent of effects was recently shown to vary between different batches of berries. Here, we examine the metabolic response to two independent batches of lingonberries. Methods and results: Alterations in the phenotype and circulating metabolome elicited by three matched HFDs, two of which containing lingonberries (L1D and L2D) from different sources, were investigated. Glycemia was improved only in mice fed L1D, whereas liver function was improved and inflammation reduced in mice fed both L1D and L2D, compared to mice fed HFD. The unique improvement in glycemia elicited by L1D was associated with a 21% increase in circulating levels of fatty acids. Increased levels of phosphatidylcholines (62%) and lysophosphatidylcholines (28%) and decreased levels of serine (−13%) and sphingomyelins (−26%) were observed in mice fed L1D and L2D, as compared to HFD. Conclusion: The unique improvement in glycemia in mice fed L1D was associated with a normal metabolic control with an altered set point. Moreover, the batch-independent reduction in liver steatosis and inflammation, was associated with an altered sphingomyelin metabolism.

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Contribution to journal
publication status
published
subject
keywords
Berries, C57BL/6J, Mass spectrometry, Obesity, Orthogonal projections to latent structures
in
Molecular Nutrition and Food Research2004-01-01+01:00
volume
61
issue
3
publisher
John Wiley & Sons
external identifiers
  • scopus:85008258369
  • wos:000398095000020
ISSN
1613-4125
DOI
10.1002/mnfr.201600442
language
English
LU publication?
yes
id
0573b2f2-1070-492f-b4d1-daa31ed2f751
date added to LUP
2017-03-13 08:49:09
date last changed
2018-01-07 11:55:01
@article{0573b2f2-1070-492f-b4d1-daa31ed2f751,
  abstract     = {<p>Scope: Lingonberries have been shown to reduce the detrimental effects of high-fat diet (HFD) on weight gain, plasma glucose, and inflammation. However, the extent of effects was recently shown to vary between different batches of berries. Here, we examine the metabolic response to two independent batches of lingonberries. Methods and results: Alterations in the phenotype and circulating metabolome elicited by three matched HFDs, two of which containing lingonberries (L1D and L2D) from different sources, were investigated. Glycemia was improved only in mice fed L1D, whereas liver function was improved and inflammation reduced in mice fed both L1D and L2D, compared to mice fed HFD. The unique improvement in glycemia elicited by L1D was associated with a 21% increase in circulating levels of fatty acids. Increased levels of phosphatidylcholines (62%) and lysophosphatidylcholines (28%) and decreased levels of serine (−13%) and sphingomyelins (−26%) were observed in mice fed L1D and L2D, as compared to HFD. Conclusion: The unique improvement in glycemia in mice fed L1D was associated with a normal metabolic control with an altered set point. Moreover, the batch-independent reduction in liver steatosis and inflammation, was associated with an altered sphingomyelin metabolism.</p>},
  articleno    = {1600442},
  author       = {Alhamimi, Said and HEYMAN, LOVISA and Plaza, Merichel and Turner, Charlotta and Berger, Karin and Spégel, Peter},
  issn         = {1613-4125},
  keyword      = {Berries,C57BL/6J,Mass spectrometry,Obesity,Orthogonal projections to latent structures},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {John Wiley & Sons},
  series       = {Molecular Nutrition and Food Research2004-01-01+01:00},
  title        = {Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets},
  url          = {http://dx.doi.org/10.1002/mnfr.201600442},
  volume       = {61},
  year         = {2017},
}