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Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach

Tovar, Juscelino LU ; de Mello, Vanessa; Nilsson, Anne LU ; Johansson, Maria LU ; Paananen, Jussi; Lehtonen, Marko; Hanhineva, Kati and Björck, Inger LU (2017) In Molecular Nutrition and Food Research 61(2).
Abstract

Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. Methods and results: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD. Fasting plasma samples were analyzed with nontargeted metabolite profiling at baseline and at the end (4 wk) of each diet... (More)

Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. Methods and results: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD. Fasting plasma samples were analyzed with nontargeted metabolite profiling at baseline and at the end (4 wk) of each diet period by LC coupled to quadrupole-TOF-MS system, revealing a vast impact of MFD on metabolic homeostasis. Main metabolite classes affected included acylcarnitines, furan fatty acids, phospholipids (plasmalogens, phosphatidylcholines, phosphatidylethanolamines), and various low-molecular weight products from the bioactivity of gut microbiota. Circulating levels of several of these metabolites correlated with changes in clinical blood lipid biomarkers. Conclusions: The metabolomics approach revealed that consumption of MFD affected different areas of metabolism, highlighting the impact of a healthy diet on plasma metabolome. This seems linked to reduced cardiometabolic risk and provides mechanistic insight into the effects of MFD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiometabolic diseases, Dietary prevention, Functional foods, Metabolic syndrome, Plasma metabolomics
in
Molecular Nutrition and Food Research
volume
61
issue
2
publisher
John Wiley & Sons
external identifiers
  • scopus:84999779286
  • wos:000394840800019
ISSN
1613-4125
DOI
10.1002/mnfr.201600552
language
English
LU publication?
yes
id
06ea6345-49b7-4da7-b930-89139c94d77f
date added to LUP
2017-02-20 10:50:20
date last changed
2017-11-05 05:14:00
@article{06ea6345-49b7-4da7-b930-89139c94d77f,
  abstract     = {<p>Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic determinants related to the effects of MFD. Methods and results: Forty-four overweight healthy volunteers completed a randomized crossover intervention comparing MFD with a control diet devoid of the active components of MFD. Fasting plasma samples were analyzed with nontargeted metabolite profiling at baseline and at the end (4 wk) of each diet period by LC coupled to quadrupole-TOF-MS system, revealing a vast impact of MFD on metabolic homeostasis. Main metabolite classes affected included acylcarnitines, furan fatty acids, phospholipids (plasmalogens, phosphatidylcholines, phosphatidylethanolamines), and various low-molecular weight products from the bioactivity of gut microbiota. Circulating levels of several of these metabolites correlated with changes in clinical blood lipid biomarkers. Conclusions: The metabolomics approach revealed that consumption of MFD affected different areas of metabolism, highlighting the impact of a healthy diet on plasma metabolome. This seems linked to reduced cardiometabolic risk and provides mechanistic insight into the effects of MFD.</p>},
  articleno    = {1600552},
  author       = {Tovar, Juscelino and de Mello, Vanessa and Nilsson, Anne and Johansson, Maria and Paananen, Jussi and Lehtonen, Marko and Hanhineva, Kati and Björck, Inger},
  issn         = {1613-4125},
  keyword      = {Cardiometabolic diseases,Dietary prevention,Functional foods,Metabolic syndrome,Plasma metabolomics},
  language     = {eng},
  month        = {02},
  number       = {2},
  publisher    = {John Wiley & Sons},
  series       = {Molecular Nutrition and Food Research},
  title        = {Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach},
  url          = {http://dx.doi.org/10.1002/mnfr.201600552},
  volume       = {61},
  year         = {2017},
}