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Spectral analysis of body movement during deep brain stimulation in Parkinson's disease

Patel, Mitesh ; Nilsson, Maria H. LU ; Rehncrona, Stig LU ; Tjernström, Fredrik LU ; Magnusson, Måns LU ; Johansson, Rolf LU and Fransson, Per Anders LU (2021) In Gait and Posture 86. p.217-225
Abstract

Background: The characteristics of Parkinson's disease (PD) include postural instability and resting tremor. However, reductions of tremor amplitude do not always improve postural stability. Research question: What is the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on spectral analysis of body movement in patients with PD when tested without anti-PD medication? The effect of visual cues was also studied. Methods: Ten patients with PD (mean age 64.3 years, range 59−69 years) and 17 control participants (mean age 71.2 years, range 65–79 years) were recruited. Spectral power following a period of quiet stance (35 s) was analysed in three different spectral power bands (0−4 Hz, 4−7 Hz and 7−25 Hz). Motion markers... (More)

Background: The characteristics of Parkinson's disease (PD) include postural instability and resting tremor. However, reductions of tremor amplitude do not always improve postural stability. Research question: What is the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on spectral analysis of body movement in patients with PD when tested without anti-PD medication? The effect of visual cues was also studied. Methods: Ten patients with PD (mean age 64.3 years, range 59−69 years) and 17 control participants (mean age 71.2 years, range 65–79 years) were recruited. Spectral power following a period of quiet stance (35 s) was analysed in three different spectral power bands (0−4 Hz, 4−7 Hz and 7−25 Hz). Motion markers were secured to the head, shoulder, hip, and knee, which recorded movements in two directions, the anteroposterior and lateral. Results: DBS STN significantly changed the spectral distribution pattern across the body in the anteroposterior (p = 0.029) and lateral directions (p ≤ 0.003). DBS predominantly reduced spectral power at the head (p ≤ 0.037) and shoulder (p ≤ 0.031) in the lateral direction. The spectral power of the lower and upper body in patients with PD, with DBS ON, were more similar to the control group, than to DBS OFF. Visual cues mainly reduced spectral power in the anteroposterior direction at the shoulder (p ≤ 0.041) in controls and in patients with PD with DBS ON. Significance: There is an altered postural strategy in patients with PD with DBS ON as shown by an altered spectral power distribution pattern across body segments and a reduction of spectral power in the lateral direction at the head and shoulder. A reduction of spectral power in controls and in patients with PD with DBS ON suggests that visual cues are able to reduce spectral power to some extent, but not with DBS OFF where postural sway and power are larger.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Body movement, Deep brain stimulation, Fast-Fourier transformation, Parkinson disease, Spectral analysis
in
Gait and Posture
volume
86
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85102849513
  • pmid:33765547
ISSN
0966-6362
DOI
10.1016/j.gaitpost.2021.03.023
language
English
LU publication?
yes
id
08684736-0c01-43f5-9742-9d4b6f9b2f2d
date added to LUP
2021-03-30 12:21:19
date last changed
2021-06-08 04:06:07
@article{08684736-0c01-43f5-9742-9d4b6f9b2f2d,
  abstract     = {<p>Background: The characteristics of Parkinson's disease (PD) include postural instability and resting tremor. However, reductions of tremor amplitude do not always improve postural stability. Research question: What is the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on spectral analysis of body movement in patients with PD when tested without anti-PD medication? The effect of visual cues was also studied. Methods: Ten patients with PD (mean age 64.3 years, range 59−69 years) and 17 control participants (mean age 71.2 years, range 65–79 years) were recruited. Spectral power following a period of quiet stance (35 s) was analysed in three different spectral power bands (0−4 Hz, 4−7 Hz and 7−25 Hz). Motion markers were secured to the head, shoulder, hip, and knee, which recorded movements in two directions, the anteroposterior and lateral. Results: DBS STN significantly changed the spectral distribution pattern across the body in the anteroposterior (p = 0.029) and lateral directions (p ≤ 0.003). DBS predominantly reduced spectral power at the head (p ≤ 0.037) and shoulder (p ≤ 0.031) in the lateral direction. The spectral power of the lower and upper body in patients with PD, with DBS ON, were more similar to the control group, than to DBS OFF. Visual cues mainly reduced spectral power in the anteroposterior direction at the shoulder (p ≤ 0.041) in controls and in patients with PD with DBS ON. Significance: There is an altered postural strategy in patients with PD with DBS ON as shown by an altered spectral power distribution pattern across body segments and a reduction of spectral power in the lateral direction at the head and shoulder. A reduction of spectral power in controls and in patients with PD with DBS ON suggests that visual cues are able to reduce spectral power to some extent, but not with DBS OFF where postural sway and power are larger.</p>},
  author       = {Patel, Mitesh and Nilsson, Maria H. and Rehncrona, Stig and Tjernström, Fredrik and Magnusson, Måns and Johansson, Rolf and Fransson, Per Anders},
  issn         = {0966-6362},
  language     = {eng},
  pages        = {217--225},
  publisher    = {Elsevier},
  series       = {Gait and Posture},
  title        = {Spectral analysis of body movement during deep brain stimulation in Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/j.gaitpost.2021.03.023},
  doi          = {10.1016/j.gaitpost.2021.03.023},
  volume       = {86},
  year         = {2021},
}