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Enhanced absorption of long-chain polyunsaturated fatty acids following consumption of functional milk formula, pre-digested with immobilized lipase ex vivo, in an exocrine pancreatic insufficient (EPI) pig model

Goncharova, Kateryna LU ; Kirko, Siarhei; Grujic, Danica; Kardas, Marek; Grochowska-Niedworok, Elżbieta; Prykhodko, Olena LU ; Woliński, Jarosław; Ushakova, Galyna; Lozinska, Liudmyla LU and Pierzynowski, Stefan G. LU (2017) In Journal of Functional Foods 34. p.422-430
Abstract

An exocrine pancreatic insufficient (EPI) pig model was used in the study. The effects of milk formula pre-digestion with immobilized microbial lipase, on the absorption and tissue accretion of long chain polyunsaturated fatty acids (LCPUFA) were assessed. Thirteen male EPI pigs, 10 weeks of age, were used in the study. Six healthy pigs, 6 weeks of age, were used as controls. The pigs were fed either a regular or a pre-digested milk formula. The formula pre-digestion resulted in the decreased faecal total fat and LCPUFA excretion (by 43% and 38% respectively), increased plasma and tissue LCPUFA content (up to 38%). In conclusion, we postulate that feeding a pre-digested milk formula, is an efficient method to develop a functional milk... (More)

An exocrine pancreatic insufficient (EPI) pig model was used in the study. The effects of milk formula pre-digestion with immobilized microbial lipase, on the absorption and tissue accretion of long chain polyunsaturated fatty acids (LCPUFA) were assessed. Thirteen male EPI pigs, 10 weeks of age, were used in the study. Six healthy pigs, 6 weeks of age, were used as controls. The pigs were fed either a regular or a pre-digested milk formula. The formula pre-digestion resulted in the decreased faecal total fat and LCPUFA excretion (by 43% and 38% respectively), increased plasma and tissue LCPUFA content (up to 38%). In conclusion, we postulate that feeding a pre-digested milk formula, is an efficient method to develop a functional milk formula, the consumption of which will ensure an increase in total fat absorption (in particular LCPUFA) in human infants as was indicated in the present study in the EPI pig model.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Exocrine pancreatic insufficiency, Fat absorption, Immobilized microbial lipase, Long chain polyunsaturated fatty acids, Nutritional milk formula
in
Journal of Functional Foods
volume
34
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85019161251
  • wos:000403383800046
ISSN
1756-4646
DOI
10.1016/j.jff.2017.05.008
language
English
LU publication?
yes
id
0938bdf4-e19c-4d52-9be8-c782b286b6a1
date added to LUP
2017-06-08 07:16:25
date last changed
2017-09-18 11:39:10
@article{0938bdf4-e19c-4d52-9be8-c782b286b6a1,
  abstract     = {<p>An exocrine pancreatic insufficient (EPI) pig model was used in the study. The effects of milk formula pre-digestion with immobilized microbial lipase, on the absorption and tissue accretion of long chain polyunsaturated fatty acids (LCPUFA) were assessed. Thirteen male EPI pigs, 10 weeks of age, were used in the study. Six healthy pigs, 6 weeks of age, were used as controls. The pigs were fed either a regular or a pre-digested milk formula. The formula pre-digestion resulted in the decreased faecal total fat and LCPUFA excretion (by 43% and 38% respectively), increased plasma and tissue LCPUFA content (up to 38%). In conclusion, we postulate that feeding a pre-digested milk formula, is an efficient method to develop a functional milk formula, the consumption of which will ensure an increase in total fat absorption (in particular LCPUFA) in human infants as was indicated in the present study in the EPI pig model.</p>},
  author       = {Goncharova, Kateryna and Kirko, Siarhei and Grujic, Danica and Kardas, Marek and Grochowska-Niedworok, Elżbieta and Prykhodko, Olena and Woliński, Jarosław and Ushakova, Galyna and Lozinska, Liudmyla and Pierzynowski, Stefan G.},
  issn         = {1756-4646},
  keyword      = {Exocrine pancreatic insufficiency,Fat absorption,Immobilized microbial lipase,Long chain polyunsaturated fatty acids,Nutritional milk formula},
  language     = {eng},
  month        = {07},
  pages        = {422--430},
  publisher    = {Elsevier},
  series       = {Journal of Functional Foods},
  title        = {Enhanced absorption of long-chain polyunsaturated fatty acids following consumption of functional milk formula, pre-digested with immobilized lipase ex vivo, in an exocrine pancreatic insufficient (EPI) pig model},
  url          = {http://dx.doi.org/10.1016/j.jff.2017.05.008},
  volume       = {34},
  year         = {2017},
}