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Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat

Andersson, G ; Garwicz, Martin LU and Hesslow, Germund LU (1988) In Experimental Brain Research 72(3). p.450-456
Abstract
1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition... (More)
1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebellum, Inferior olive, Interposito-olivary pathway, Brachium conjunctivum, GABA
in
Experimental Brain Research
volume
72
issue
3
pages
450 - 456
publisher
Springer
external identifiers
  • pmid:3234498
  • scopus:0023732776
ISSN
0014-4819
DOI
10.1007/BF00250590
language
English
LU publication?
yes
id
0aaa3181-c251-4ea9-8392-0a21fa2bf9fd (old id 1104245)
date added to LUP
2016-04-01 11:48:19
date last changed
2021-09-19 05:13:40
@article{0aaa3181-c251-4ea9-8392-0a21fa2bf9fd,
  abstract     = {{1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.}},
  author       = {{Andersson, G and Garwicz, Martin and Hesslow, Germund}},
  issn         = {{0014-4819}},
  keywords     = {{Cerebellum; Inferior olive; Interposito-olivary pathway; Brachium conjunctivum; GABA}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{450--456}},
  publisher    = {{Springer}},
  series       = {{Experimental Brain Research}},
  title        = {{Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat}},
  url          = {{http://dx.doi.org/10.1007/BF00250590}},
  doi          = {{10.1007/BF00250590}},
  volume       = {{72}},
  year         = {{1988}},
}