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Evaluation of cellular stress responses in magnetomotive ultrasound

Sjöstrand, Sandra LU ; Stephanie Zeller, Kathrin LU orcid ; Evertsson, Maria LU and Jansson, Tomas LU (2022) In Nanomedicine 17(14). p.1013-1025
Abstract

Early and accurate diagnoses are important for successful cancer treatment. Lymph node involvement is often critical, and magnetomotive ultrasound (MMUS) has been proposed for its detection and characterization. MMUS relies on a magnetic contrast agent, for example, iron oxide nanoparticles, delivered to the tissue of interest, magnetically set in motion and detected using ultrasound. The magneto-mechanical interaction has not previously been evaluated on a cellular level. Here we demonstrate uptake and dose-dependent retention of magnetic nanoparticles in two human adenocarcinoma cell lines, with <10% cytotoxicity which did not increase following magnetic excitation. Further, the oxidative stress levels were not affected by magnetic... (More)

Early and accurate diagnoses are important for successful cancer treatment. Lymph node involvement is often critical, and magnetomotive ultrasound (MMUS) has been proposed for its detection and characterization. MMUS relies on a magnetic contrast agent, for example, iron oxide nanoparticles, delivered to the tissue of interest, magnetically set in motion and detected using ultrasound. The magneto-mechanical interaction has not previously been evaluated on a cellular level. Here we demonstrate uptake and dose-dependent retention of magnetic nanoparticles in two human adenocarcinoma cell lines, with <10% cytotoxicity which did not increase following magnetic excitation. Further, the oxidative stress levels were not affected by magnetic particles or force. Thus, we found no evidence of adverse effects from the magneto-mechanical interactions under these conditions.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Caco-2, cancer, HT-29, imaging, magnetomotive ultrasound
in
Nanomedicine
volume
17
issue
14
pages
13 pages
publisher
Future Medicine Ltd.
external identifiers
  • pmid:36043897
  • scopus:85140274534
ISSN
1743-5889
DOI
10.2217/nnm-2021-0455
language
English
LU publication?
yes
id
0bb0fa08-d906-421f-a074-b14f4bb2b012
date added to LUP
2022-12-16 15:19:05
date last changed
2024-04-03 20:52:15
@article{0bb0fa08-d906-421f-a074-b14f4bb2b012,
  abstract     = {{<p>Early and accurate diagnoses are important for successful cancer treatment. Lymph node involvement is often critical, and magnetomotive ultrasound (MMUS) has been proposed for its detection and characterization. MMUS relies on a magnetic contrast agent, for example, iron oxide nanoparticles, delivered to the tissue of interest, magnetically set in motion and detected using ultrasound. The magneto-mechanical interaction has not previously been evaluated on a cellular level. Here we demonstrate uptake and dose-dependent retention of magnetic nanoparticles in two human adenocarcinoma cell lines, with &lt;10% cytotoxicity which did not increase following magnetic excitation. Further, the oxidative stress levels were not affected by magnetic particles or force. Thus, we found no evidence of adverse effects from the magneto-mechanical interactions under these conditions.</p>}},
  author       = {{Sjöstrand, Sandra and Stephanie Zeller, Kathrin and Evertsson, Maria and Jansson, Tomas}},
  issn         = {{1743-5889}},
  keywords     = {{Caco-2; cancer; HT-29; imaging; magnetomotive ultrasound}},
  language     = {{eng}},
  number       = {{14}},
  pages        = {{1013--1025}},
  publisher    = {{Future Medicine Ltd.}},
  series       = {{Nanomedicine}},
  title        = {{Evaluation of cellular stress responses in magnetomotive ultrasound}},
  url          = {{http://dx.doi.org/10.2217/nnm-2021-0455}},
  doi          = {{10.2217/nnm-2021-0455}},
  volume       = {{17}},
  year         = {{2022}},
}