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Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing

Hesslow, Germund LU ; Jirenhed, Dan Anders LU and Johansson, Fredrik LU (2021) p.1335-1344
Abstract

During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cerebellum, Classical conditioning, Purkinje cells, Simple spikes, Timing
host publication
Handbook of the Cerebellum and Cerebellar Disorders : Second Edition: Volume 3 - Second Edition: Volume 3
pages
10 pages
publisher
Springer International Publishing
external identifiers
  • scopus:85153661403
ISBN
9783030238094
9783030238100
DOI
10.1007/978-3-030-23810-0_115
language
English
LU publication?
yes
id
0cf3d9ea-4ebc-44bf-86c6-0634fafa7acd
date added to LUP
2023-07-21 15:04:03
date last changed
2024-03-22 22:36:25
@inbook{0cf3d9ea-4ebc-44bf-86c6-0634fafa7acd,
  abstract     = {{<p>During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.</p>}},
  author       = {{Hesslow, Germund and Jirenhed, Dan Anders and Johansson, Fredrik}},
  booktitle    = {{Handbook of the Cerebellum and Cerebellar Disorders : Second Edition: Volume 3}},
  isbn         = {{9783030238094}},
  keywords     = {{Cerebellum; Classical conditioning; Purkinje cells; Simple spikes; Timing}},
  language     = {{eng}},
  pages        = {{1335--1344}},
  publisher    = {{Springer International Publishing}},
  title        = {{Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing}},
  url          = {{http://dx.doi.org/10.1007/978-3-030-23810-0_115}},
  doi          = {{10.1007/978-3-030-23810-0_115}},
  year         = {{2021}},
}