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Hypertension and cardiovascular diseases in Swedish persons with haemophilia — A longitudinal registry study

Lövdahl, Susanna LU ; Henriksson, Karin M.; Baghaei, Fariba; Holmström, Margareta; Berntorp, Erik LU and Astermark, Jan LU (2019) In Thrombosis Research 181(Sept.). p.106-111
Abstract

Introduction: Data on the prevalence of hypertension and cardiovascular diseases (CVD) among persons with haemophilia (PWH) vary. Sweden has a long tradition of maintaining population-based data registries, and there is extensive follow-up of haemophilia patients due to the use of prophylaxis over decades. We evaluated the prevalence of these diseases among Swedish PWH compared to matched controls using a longitudinal study design. Methods: Data were obtained from the National Patient Registry and linked to records of persons with haemophilia enrolled in the haemophilia centres. For each subject, five gender and age matched controls were identified. Results: We identified 193 (19.7%) diagnoses of hypertension in PWH born in 1978 or... (More)

Introduction: Data on the prevalence of hypertension and cardiovascular diseases (CVD) among persons with haemophilia (PWH) vary. Sweden has a long tradition of maintaining population-based data registries, and there is extensive follow-up of haemophilia patients due to the use of prophylaxis over decades. We evaluated the prevalence of these diseases among Swedish PWH compared to matched controls using a longitudinal study design. Methods: Data were obtained from the National Patient Registry and linked to records of persons with haemophilia enrolled in the haemophilia centres. For each subject, five gender and age matched controls were identified. Results: We identified 193 (19.7%) diagnoses of hypertension in PWH born in 1978 or earlier over ≥30 years compared with 550 (11.2%) among controls. The median ages and interquartile ranges were 60.0 (42.8, 69.9) and 57.2 (42.6, 70.6) years. The hazard rate (HR) for hypertension, PWH vs. controls, was 2.1, 95% CI: [1.8; 2.5], p < 0.001. The findings were similar in subgroup analyses of patients with non-severe and severe haemophilia with or without HIV and/or viral hepatitis. Angina pectoris was diagnosed in 69 (4.8%) of patients censored at age 75 compared with 311 (4.3%) in controls, and myocardial ischemia in 84 (5.9%) compared with 442 (6.2%). As a cause of death, the HR for myocardial ischemia, comparing PWH and controls, was 0.58, 95% CI: [0.42, 0.80], p = 0.001. Conclusion: Our data support an increased prevalence of hypertension among persons with haemophilia. The prevalence of CVD seems to be similar to that of controls, but with lower mortality.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease, Haemophilia, Hepatitis, HIV, Hypertension
in
Thrombosis Research
volume
181
issue
Sept.
pages
106 - 111
publisher
Elsevier Ltd
external identifiers
  • scopus:85070073531
ISSN
0049-3848
DOI
10.1016/j.thromres.2019.07.017
language
English
LU publication?
yes
id
0da8e5db-4ad4-4a13-ad80-dae0a3707cda
date added to LUP
2019-08-30 10:27:32
date last changed
2019-09-04 04:49:37
@article{0da8e5db-4ad4-4a13-ad80-dae0a3707cda,
  abstract     = {<p>Introduction: Data on the prevalence of hypertension and cardiovascular diseases (CVD) among persons with haemophilia (PWH) vary. Sweden has a long tradition of maintaining population-based data registries, and there is extensive follow-up of haemophilia patients due to the use of prophylaxis over decades. We evaluated the prevalence of these diseases among Swedish PWH compared to matched controls using a longitudinal study design. Methods: Data were obtained from the National Patient Registry and linked to records of persons with haemophilia enrolled in the haemophilia centres. For each subject, five gender and age matched controls were identified. Results: We identified 193 (19.7%) diagnoses of hypertension in PWH born in 1978 or earlier over ≥30 years compared with 550 (11.2%) among controls. The median ages and interquartile ranges were 60.0 (42.8, 69.9) and 57.2 (42.6, 70.6) years. The hazard rate (HR) for hypertension, PWH vs. controls, was 2.1, 95% CI: [1.8; 2.5], p &lt; 0.001. The findings were similar in subgroup analyses of patients with non-severe and severe haemophilia with or without HIV and/or viral hepatitis. Angina pectoris was diagnosed in 69 (4.8%) of patients censored at age 75 compared with 311 (4.3%) in controls, and myocardial ischemia in 84 (5.9%) compared with 442 (6.2%). As a cause of death, the HR for myocardial ischemia, comparing PWH and controls, was 0.58, 95% CI: [0.42, 0.80], p = 0.001. Conclusion: Our data support an increased prevalence of hypertension among persons with haemophilia. The prevalence of CVD seems to be similar to that of controls, but with lower mortality.</p>},
  author       = {Lövdahl, Susanna and Henriksson, Karin M. and Baghaei, Fariba and Holmström, Margareta and Berntorp, Erik and Astermark, Jan},
  issn         = {0049-3848},
  keyword      = {Cardiovascular disease,Haemophilia,Hepatitis,HIV,Hypertension},
  language     = {eng},
  number       = {Sept.},
  pages        = {106--111},
  publisher    = {Elsevier Ltd},
  series       = {Thrombosis Research},
  title        = {Hypertension and cardiovascular diseases in Swedish persons with haemophilia — A longitudinal registry study},
  url          = {http://dx.doi.org/10.1016/j.thromres.2019.07.017},
  volume       = {181},
  year         = {2019},
}