Tracing Renal Cell Carcinomas back to the Nephron
(2018) In Trends in Cancer 4(7). p.472-484- Abstract
Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these... (More)
Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these relate to cell-of-origin and renal repair programs.
(Less)
- author
- Lindgren, David LU ; Sjölund, Jonas LU and Axelson, Håkan LU
- organization
- publishing date
- 2018-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Cancer
- volume
- 4
- issue
- 7
- pages
- 472 - 484
- publisher
- Cell Press
- external identifiers
-
- pmid:29937046
- scopus:85047956648
- ISSN
- 2405-8033
- DOI
- 10.1016/j.trecan.2018.05.003
- language
- English
- LU publication?
- yes
- id
- 0e306556-2cb9-4b63-813a-7d946300b59c
- date added to LUP
- 2018-06-15 13:36:13
- date last changed
- 2024-06-24 15:56:09
@article{0e306556-2cb9-4b63-813a-7d946300b59c, abstract = {{<p>Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these relate to cell-of-origin and renal repair programs.</p>}}, author = {{Lindgren, David and Sjölund, Jonas and Axelson, Håkan}}, issn = {{2405-8033}}, language = {{eng}}, number = {{7}}, pages = {{472--484}}, publisher = {{Cell Press}}, series = {{Trends in Cancer}}, title = {{Tracing Renal Cell Carcinomas back to the Nephron}}, url = {{http://dx.doi.org/10.1016/j.trecan.2018.05.003}}, doi = {{10.1016/j.trecan.2018.05.003}}, volume = {{4}}, year = {{2018}}, }