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Regional values of diffusional kurtosis estimates in the healthy brain.

Lätt, Jimmy LU ; Nilsson, Markus LU ; Wirestam, Ronnie LU ; Ståhlberg, Freddy LU ; Karlsson, Nils; Johansson, Mikael LU ; Sundgren, Pia LU and van Westen, Danielle LU (2013) In Journal of Magnetic Resonance Imaging 37(3). p.610-618
Abstract
PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19-64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2) /ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a... (More)
PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19-64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2) /ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2012. © 2012 Wiley Periodicals, Inc. (Less)
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author
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type
Contribution to journal
publication status
published
subject
in
Journal of Magnetic Resonance Imaging
volume
37
issue
3
pages
610 - 618
publisher
John Wiley & Sons
external identifiers
  • wos:000315220000008
  • pmid:23055442
  • scopus:84874224852
ISSN
1522-2586
DOI
10.1002/jmri.23857
language
English
LU publication?
yes
id
0f6bf91f-5664-4068-a206-4bf2d7f42205 (old id 3160862)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23055442?dopt=Abstract
date added to LUP
2012-11-01 16:06:37
date last changed
2019-07-09 01:39:42
@article{0f6bf91f-5664-4068-a206-4bf2d7f42205,
  abstract     = {PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19-64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2) /ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2012. © 2012 Wiley Periodicals, Inc.},
  author       = {Lätt, Jimmy and Nilsson, Markus and Wirestam, Ronnie and Ståhlberg, Freddy and Karlsson, Nils and Johansson, Mikael and Sundgren, Pia and van Westen, Danielle},
  issn         = {1522-2586},
  language     = {eng},
  number       = {3},
  pages        = {610--618},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Regional values of diffusional kurtosis estimates in the healthy brain.},
  url          = {http://dx.doi.org/10.1002/jmri.23857},
  volume       = {37},
  year         = {2013},
}