Regional values of diffusional kurtosis estimates in the healthy brain.
Lätt, Jimmy LU ; Nilsson, Markus LU ; Wirestam, Ronnie LU
; Ståhlberg, Freddy
LU
; Karlsson, Nils
; Johansson, Mikael
LU
; Sundgren, Pia
LU
and van Westen, Danielle
LU
(2013)
In Journal of Magnetic Resonance Imaging
37(3).
p.610-618
- Abstract
- PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19-64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2) /ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a... (More)
- PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19-64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2) /ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2012. © 2012 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160862
- author
- Lätt, Jimmy
LU
; Nilsson, Markus
LU
; Wirestam, Ronnie
LU
; Ståhlberg, Freddy
LU
; Karlsson, Nils
; Johansson, Mikael
LU
; Sundgren, Pia
LU
and van Westen, Danielle
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Magnetic Resonance Imaging
- volume
- 37
- issue
- 3
- pages
- 610 - 618
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000315220000008
- pmid:23055442
- scopus:84874224852
- pmid:23055442
- ISSN
- 1522-2586
- DOI
- 10.1002/jmri.23857
- language
- English
- LU publication?
- yes
- id
- 0f6bf91f-5664-4068-a206-4bf2d7f42205 (old id 3160862)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23055442?dopt=Abstract
- date added to LUP
- 2016-04-01 11:15:39
- date last changed
- 2022-05-06 05:36:35
@article{0f6bf91f-5664-4068-a206-4bf2d7f42205,
abstract = {{PURPOSE: To provide estimates of the diffusional kurtosis in the healthy brain in anatomically defined areas and list these along previously reported values in pathologies. MATERIALS AND METHODS: Thirty-six volunteers (mean age = 33.1 years; range, 19-64 years) underwent diffusional kurtosis imaging. Mean kurtosis (MK), radial kurtosis (RK), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA) were determined in 26 anatomical structures. Parameter estimates were assessed regarding age dependence. RESULTS: MK varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head, MD varied from 0.68 to 0.62 μm(2) /ms and FA from 0.87 to 0.29. MK, and FA showed a strong positive correlation, RK and RD a strong negative correlation. Parameter estimates showed age correlation in some regions; also the average MK and RK for all WM and all GM areas, respectively, were negatively correlated with age. CONCLUSION: DKI parameter estimates MK and RK varied depending on the anatomical region and varied with age in pooled WM and GM data. MK estimates in the internal capsule, corpus callosum, and thalamus were consistent with previous studies. The range of values of MK and RK in healthy brain overlapped with that in pathologies. J. Magn. Reson. Imaging 2012. © 2012 Wiley Periodicals, Inc.}},
author = {{Lätt, Jimmy and Nilsson, Markus and Wirestam, Ronnie and Ståhlberg, Freddy and Karlsson, Nils and Johansson, Mikael and Sundgren, Pia and van Westen, Danielle}},
issn = {{1522-2586}},
language = {{eng}},
number = {{3}},
pages = {{610--618}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Magnetic Resonance Imaging}},
title = {{Regional values of diffusional kurtosis estimates in the healthy brain.}},
url = {{http://dx.doi.org/10.1002/jmri.23857}},
doi = {{10.1002/jmri.23857}},
volume = {{37}},
year = {{2013}},
}