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Acute pancreatitis - from cellular signalling to complicated clinical course.

Andersson, Roland LU ; Andersson, Bodil LU ; Andersson, Ellen LU ; Axelsson, Jakob B LU ; Eckerwall, Gunilla LU and Tingstedt, Bobby LU (2007) In HPB 9(6). p.414-420
Abstract
Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve outcome, diagnostic possibilities, their indications and optimal timing, and the systemic inflammatory reaction (systemic inflammatory response syndrome - SIRS) and its effect on the concomitant course of the disease and potential development of organ failure. The role of the gut has been suggested to be important in severe AP, but has recently been... (More)
Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve outcome, diagnostic possibilities, their indications and optimal timing, and the systemic inflammatory reaction (systemic inflammatory response syndrome - SIRS) and its effect on the concomitant course of the disease and potential development of organ failure. The role of the gut has been suggested to be important in severe AP, but has recently been somewhat questioned. Despite extensive research, pharmacological and medical intervention of proven clinical value is scarce. Various aspects on surgical interventions, including endoscopic sphincterotomy, cholecystectomy and necrosectomy, as regards indications and timing, will be reviewed. Last, but not least, are the management of late complications and long-term outcome for patients with especially severe AP. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
HPB
volume
9
issue
6
pages
414 - 420
publisher
Informa Healthcare
external identifiers
  • pmid:18345287
  • scopus:36749022215
ISSN
1477-2574
DOI
10.1080/13651820701713766
language
English
LU publication?
yes
id
78c75b6a-bfc8-4372-a15a-d9028f875f6d (old id 1052397)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18345287?dopt=Abstract
date added to LUP
2008-04-01 08:42:25
date last changed
2017-01-01 07:34:44
@article{78c75b6a-bfc8-4372-a15a-d9028f875f6d,
  abstract     = {Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve outcome, diagnostic possibilities, their indications and optimal timing, and the systemic inflammatory reaction (systemic inflammatory response syndrome - SIRS) and its effect on the concomitant course of the disease and potential development of organ failure. The role of the gut has been suggested to be important in severe AP, but has recently been somewhat questioned. Despite extensive research, pharmacological and medical intervention of proven clinical value is scarce. Various aspects on surgical interventions, including endoscopic sphincterotomy, cholecystectomy and necrosectomy, as regards indications and timing, will be reviewed. Last, but not least, are the management of late complications and long-term outcome for patients with especially severe AP.},
  author       = {Andersson, Roland and Andersson, Bodil and Andersson, Ellen and Axelsson, Jakob B and Eckerwall, Gunilla and Tingstedt, Bobby},
  issn         = {1477-2574},
  language     = {eng},
  number       = {6},
  pages        = {414--420},
  publisher    = {Informa Healthcare},
  series       = {HPB},
  title        = {Acute pancreatitis - from cellular signalling to complicated clinical course.},
  url          = {http://dx.doi.org/10.1080/13651820701713766},
  volume       = {9},
  year         = {2007},
}