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Smoking-Related Changes in Cerebral Perfusion in a Population of Elderly Men.

Siennicki-Lantz, Arkadiusz LU ; Reinprecht, Faina LU ; Wollmer, Per LU and Elmståhl, Sölve LU (2008) In Neuroepidemiology 30(2). p.84-92
Abstract
Aim: Smoking and hypertension are known causes of stroke and dementia. This study was designed to test the longitudinal effect of lifestyle factors and hypertension on cerebral blood flow (CBF) in old age. Method: A study of an unselected population cohort of 703 men, born in 1914, has been in progress since 1968 and the last clinical examination occurred at age 69. CBF was examined in 129 survivors who reached 82 years, using SPECT. Results: At the age of 69, the study subjects consisted of 36 smokers, 37 nonsmokers and 56 former smokers who had quit. Fourteen years later, there were no differences in CBF among them. The cohort was stratified into 69 hypertensive and 60 normotensive men. CBF in normotensives was lowest in smokers and... (More)
Aim: Smoking and hypertension are known causes of stroke and dementia. This study was designed to test the longitudinal effect of lifestyle factors and hypertension on cerebral blood flow (CBF) in old age. Method: A study of an unselected population cohort of 703 men, born in 1914, has been in progress since 1968 and the last clinical examination occurred at age 69. CBF was examined in 129 survivors who reached 82 years, using SPECT. Results: At the age of 69, the study subjects consisted of 36 smokers, 37 nonsmokers and 56 former smokers who had quit. Fourteen years later, there were no differences in CBF among them. The cohort was stratified into 69 hypertensive and 60 normotensive men. CBF in normotensives was lowest in smokers and highest in nonsmokers. No CBF differences were observed in hypertensive men regarding smoking, but their CBF was as low as in normotensive smokers. Hypertensives had a higher BMI, and higher blood glucose and triglyceride levels, but lower alcohol consumption at 69 and a lower ankle-brachial pressure index at 82 years. Alcohol consumption was highest in normotensive smokers. Conclusion: Smoking and high alcohol consumption in normotensive men are correlated to low CBF in senescence. Low CBF in hypertensive men regardless of smoking may be due to a high vascular risk profile. Copyright (c) 2008 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroepidemiology
volume
30
issue
2
pages
84 - 92
publisher
Karger
external identifiers
  • pmid:18311087
  • wos:000254417700003
  • scopus:41849125603
ISSN
1423-0208
DOI
10.1159/000118944
language
English
LU publication?
yes
id
3a8efedd-ac5c-45fc-872c-d71bc305640e (old id 1052913)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18311087?dopt=Abstract
date added to LUP
2008-04-03 07:54:10
date last changed
2017-01-01 07:32:39
@article{3a8efedd-ac5c-45fc-872c-d71bc305640e,
  abstract     = {Aim: Smoking and hypertension are known causes of stroke and dementia. This study was designed to test the longitudinal effect of lifestyle factors and hypertension on cerebral blood flow (CBF) in old age. Method: A study of an unselected population cohort of 703 men, born in 1914, has been in progress since 1968 and the last clinical examination occurred at age 69. CBF was examined in 129 survivors who reached 82 years, using SPECT. Results: At the age of 69, the study subjects consisted of 36 smokers, 37 nonsmokers and 56 former smokers who had quit. Fourteen years later, there were no differences in CBF among them. The cohort was stratified into 69 hypertensive and 60 normotensive men. CBF in normotensives was lowest in smokers and highest in nonsmokers. No CBF differences were observed in hypertensive men regarding smoking, but their CBF was as low as in normotensive smokers. Hypertensives had a higher BMI, and higher blood glucose and triglyceride levels, but lower alcohol consumption at 69 and a lower ankle-brachial pressure index at 82 years. Alcohol consumption was highest in normotensive smokers. Conclusion: Smoking and high alcohol consumption in normotensive men are correlated to low CBF in senescence. Low CBF in hypertensive men regardless of smoking may be due to a high vascular risk profile. Copyright (c) 2008 S. Karger AG, Basel.},
  author       = {Siennicki-Lantz, Arkadiusz and Reinprecht, Faina and Wollmer, Per and Elmståhl, Sölve},
  issn         = {1423-0208},
  language     = {eng},
  number       = {2},
  pages        = {84--92},
  publisher    = {Karger},
  series       = {Neuroepidemiology},
  title        = {Smoking-Related Changes in Cerebral Perfusion in a Population of Elderly Men.},
  url          = {http://dx.doi.org/10.1159/000118944},
  volume       = {30},
  year         = {2008},
}