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Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group.

Mertens, Fredrik LU ; Strömberg, Ulf LU ; Mandahl, Nils LU ; Cin, Paola Dal; De Wever, Ivo; Fletcher, Christopher D M; Mitelman, Felix LU ; Rosai, Juan; Rydholm, Anders LU and Sciot, Raf, et al. (2002) In Cancer Research 62(14). p.3980-3984
Abstract
Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact of cytogenetic features detected in these tumors. A total of 239 benign and 221 malignant soft tissue tumors with clonal chromosome aberrations were subdivided according to general karyotypic features, such as degree of complexity and ploidy level, and rearrangements of specific chromosomal regions. The cytogenetic variables were analyzed regarding clinical outcome, using time to metastasis as the end point. Selected variables... (More)
Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact of cytogenetic features detected in these tumors. A total of 239 benign and 221 malignant soft tissue tumors with clonal chromosome aberrations were subdivided according to general karyotypic features, such as degree of complexity and ploidy level, and rearrangements of specific chromosomal regions. The cytogenetic variables were analyzed regarding clinical outcome, using time to metastasis as the end point. Selected variables were then compared with established clinicopathological predictors of metastasis development. When the entire material was considered, 167 of 268 investigated cytogenetic variables were associated with clinical outcome. Focusing on the subset of 151 patients with high-grade sarcoma, 17 variables were identified that, besides grade and size, were associated with increased risk of metastasis development. A final Cox regression analysis identified five independent cytogenetic predictors of adverse outcome; breakpoints in chromosome regions 1p1, 1q4, 14q1, and 17q2, and gain of regions 6p1/p2. An increasing effect on metastatic risk was seen with increasing involvement of the selected cytogenetic variables, even when different histopathological types were studied separately. We conclude that cytogenetic data provide independent prognostic information in soft tissue sarcomas. Furthermore, our results point to specific areas of the genome harboring genes that may influence the metastatic potential of sarcoma cells. (Less)
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Soft Tissue Neoplasms : secondary, Prognosis, Sarcoma : genetics, Soft Tissue Neoplasms : pathology, Sarcoma : secondary, Soft Tissue Neoplasms : genetics, Adolescence, Sarcoma : pathology, Adult, Child, Preschool, Female, Chromosome Aberrations, Follow-Up Studies, Human, Infant, Middle Age, Newborn, Male
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Cancer Research
volume
62
issue
14
pages
3980 - 3984
publisher
American Association for Cancer Research Inc.
external identifiers
  • pmid:12124330
  • wos:000176871500016
  • scopus:0037099526
ISSN
1538-7445
language
English
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yes
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1a160021-4075-4daa-992e-0fd35b63ce4d (old id 109398)
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http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12124330&dopt=Abstract
http://cancerres.aacrjournals.org/cgi/content/full/62/14/3980
date added to LUP
2007-07-08 12:48:57
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2017-08-27 05:27:23
@article{1a160021-4075-4daa-992e-0fd35b63ce4d,
  abstract     = {Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact of cytogenetic features detected in these tumors. A total of 239 benign and 221 malignant soft tissue tumors with clonal chromosome aberrations were subdivided according to general karyotypic features, such as degree of complexity and ploidy level, and rearrangements of specific chromosomal regions. The cytogenetic variables were analyzed regarding clinical outcome, using time to metastasis as the end point. Selected variables were then compared with established clinicopathological predictors of metastasis development. When the entire material was considered, 167 of 268 investigated cytogenetic variables were associated with clinical outcome. Focusing on the subset of 151 patients with high-grade sarcoma, 17 variables were identified that, besides grade and size, were associated with increased risk of metastasis development. A final Cox regression analysis identified five independent cytogenetic predictors of adverse outcome; breakpoints in chromosome regions 1p1, 1q4, 14q1, and 17q2, and gain of regions 6p1/p2. An increasing effect on metastatic risk was seen with increasing involvement of the selected cytogenetic variables, even when different histopathological types were studied separately. We conclude that cytogenetic data provide independent prognostic information in soft tissue sarcomas. Furthermore, our results point to specific areas of the genome harboring genes that may influence the metastatic potential of sarcoma cells.},
  author       = {Mertens, Fredrik and Strömberg, Ulf and Mandahl, Nils and Cin, Paola Dal and De Wever, Ivo and Fletcher, Christopher D M and Mitelman, Felix and Rosai, Juan and Rydholm, Anders and Sciot, Raf and Tallini, Giovanni and Van Den Berghe, Herman and Vanni, Roberta and Willén, Helena},
  issn         = {1538-7445},
  keyword      = {Soft Tissue Neoplasms : secondary,Prognosis,Sarcoma : genetics,Soft Tissue Neoplasms : pathology,Sarcoma : secondary,Soft Tissue Neoplasms : genetics,Adolescence,Sarcoma : pathology,Adult,Child,Preschool,Female,Chromosome Aberrations,Follow-Up Studies,Human,Infant,Middle Age,Newborn,Male},
  language     = {eng},
  number       = {14},
  pages        = {3980--3984},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group.},
  volume       = {62},
  year         = {2002},
}