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Neonatal delivery weight and risk of future maternal diabetes

Stuart, Andrea E.; Amer-Wåhlin, Isis and Källen, Karin B.M. LU (2018) In International Journal of Gynecology and Obstetrics 140(1). p.111-117
Abstract

Objective: To investigate associations between neonatal delivery weight and future risk of maternal type 1 or type 2 diabetes. Methods: Data included in the Swedish Medical Birth Registry and Swedish National Diabetes Registry were merged to include all women born during 1930–1989; patients with pre-existing diabetes or gestational diabetes were excluded. Cox regression analyses were performed to identify associations between the neonatal delivery weight from the most recent pregnancy and later occurrence of diabetes. Results: There were 1 873 440 patients included in the analyses. An increased risk of type 1 (hazard ratio 3.60, 95% confidence interval [CI] 3.23–4.01) or type 2 diabetes (hazard ratio 2.77, 95% CI 2.68–2.87) was observed... (More)

Objective: To investigate associations between neonatal delivery weight and future risk of maternal type 1 or type 2 diabetes. Methods: Data included in the Swedish Medical Birth Registry and Swedish National Diabetes Registry were merged to include all women born during 1930–1989; patients with pre-existing diabetes or gestational diabetes were excluded. Cox regression analyses were performed to identify associations between the neonatal delivery weight from the most recent pregnancy and later occurrence of diabetes. Results: There were 1 873 440 patients included in the analyses. An increased risk of type 1 (hazard ratio 3.60, 95% confidence interval [CI] 3.23–4.01) or type 2 diabetes (hazard ratio 2.77, 95% CI 2.68–2.87) was observed among patients who had a large for gestational age neonate compared with patients who had neonates within one standard definition of the mean weight for gestational age; the odds of developing type 1 (odds ratio 10.27, 95% CI 7.37–14.31) or type 2 diabetes (odds ratio 8.50, 95% CI 6.01–12.02) within 1 year of delivery was also increased compared with patients who had a neonate within one standard deviation of the mean weight for gestational age. Conclusions: Delivering a large for gestational age neonate was a potent risk factor for the later development of maternal type 1 or type 2 diabetes.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Large for gestational age, Maternal diabetes, Obesity
in
International Journal of Gynecology and Obstetrics
volume
140
issue
1
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:85037054643
ISSN
0020-7292
DOI
10.1002/ijgo.12337
language
English
LU publication?
yes
id
10fd4641-135d-4fcb-9ebf-53eb92e242da
date added to LUP
2018-01-02 14:06:39
date last changed
2018-01-10 11:33:32
@article{10fd4641-135d-4fcb-9ebf-53eb92e242da,
  abstract     = {<p>Objective: To investigate associations between neonatal delivery weight and future risk of maternal type 1 or type 2 diabetes. Methods: Data included in the Swedish Medical Birth Registry and Swedish National Diabetes Registry were merged to include all women born during 1930–1989; patients with pre-existing diabetes or gestational diabetes were excluded. Cox regression analyses were performed to identify associations between the neonatal delivery weight from the most recent pregnancy and later occurrence of diabetes. Results: There were 1 873 440 patients included in the analyses. An increased risk of type 1 (hazard ratio 3.60, 95% confidence interval [CI] 3.23–4.01) or type 2 diabetes (hazard ratio 2.77, 95% CI 2.68–2.87) was observed among patients who had a large for gestational age neonate compared with patients who had neonates within one standard definition of the mean weight for gestational age; the odds of developing type 1 (odds ratio 10.27, 95% CI 7.37–14.31) or type 2 diabetes (odds ratio 8.50, 95% CI 6.01–12.02) within 1 year of delivery was also increased compared with patients who had a neonate within one standard deviation of the mean weight for gestational age. Conclusions: Delivering a large for gestational age neonate was a potent risk factor for the later development of maternal type 1 or type 2 diabetes.</p>},
  author       = {Stuart, Andrea E. and Amer-Wåhlin, Isis and Källen, Karin B.M.},
  issn         = {0020-7292},
  keyword      = {Large for gestational age,Maternal diabetes,Obesity},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {111--117},
  publisher    = {Elsevier},
  series       = {International Journal of Gynecology and Obstetrics},
  title        = {Neonatal delivery weight and risk of future maternal diabetes},
  url          = {http://dx.doi.org/10.1002/ijgo.12337},
  volume       = {140},
  year         = {2018},
}