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Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat

Andersson, G; Garwicz, Martin LU and Hesslow, Germund LU (1988) In Experimental Brain Research 72(3). p.450-456
Abstract
1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition... (More)
1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebellum, Inferior olive, Interposito-olivary pathway, Brachium conjunctivum, GABA
in
Experimental Brain Research
volume
72
issue
3
pages
450 - 456
publisher
Springer
external identifiers
  • pmid:3234498
  • scopus:0023732776
ISSN
0014-4819
DOI
10.1007/BF00250590
language
English
LU publication?
yes
id
0aaa3181-c251-4ea9-8392-0a21fa2bf9fd (old id 1104245)
date added to LUP
2008-08-07 13:13:26
date last changed
2017-01-15 03:28:38
@article{0aaa3181-c251-4ea9-8392-0a21fa2bf9fd,
  abstract     = {1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.},
  author       = {Andersson, G and Garwicz, Martin and Hesslow, Germund},
  issn         = {0014-4819},
  keyword      = {Cerebellum,Inferior olive,Interposito-olivary pathway,Brachium conjunctivum,GABA},
  language     = {eng},
  number       = {3},
  pages        = {450--456},
  publisher    = {Springer},
  series       = {Experimental Brain Research},
  title        = {Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat},
  url          = {http://dx.doi.org/10.1007/BF00250590},
  volume       = {72},
  year         = {1988},
}