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Neutron capture imaging of 10B in tissue specimens

Ceberg, Crister LU ; Salford, Leif LU ; Brun, Arne LU ; Hemler, Raphael J B and Persson, Bertil R LU (1993) In Radiotherapy and Oncology 26(2). p.139-146
Abstract
Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for... (More)
Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BNCT, Glioma, Bio-distribution, Boron imaging, Track-films, Self-absorption
in
Radiotherapy and Oncology
volume
26
issue
2
pages
139 - 146
publisher
Elsevier
external identifiers
  • pmid:8465014
  • scopus:0027477816
ISSN
1879-0887
DOI
10.1016/0167-8140(93)90095-P
language
English
LU publication?
yes
id
4fa673f3-5117-461b-bc63-fc637e00e2c8 (old id 1107456)
date added to LUP
2008-07-31 09:25:05
date last changed
2017-01-01 05:09:21
@article{4fa673f3-5117-461b-bc63-fc637e00e2c8,
  abstract     = {Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined.},
  author       = {Ceberg, Crister and Salford, Leif and Brun, Arne and Hemler, Raphael J B and Persson, Bertil R},
  issn         = {1879-0887},
  keyword      = {BNCT,Glioma,Bio-distribution,Boron imaging,Track-films,Self-absorption},
  language     = {eng},
  number       = {2},
  pages        = {139--146},
  publisher    = {Elsevier},
  series       = {Radiotherapy and Oncology},
  title        = {Neutron capture imaging of 10B in tissue specimens},
  url          = {http://dx.doi.org/10.1016/0167-8140(93)90095-P},
  volume       = {26},
  year         = {1993},
}