Neutron capture imaging of 10B in tissue specimens
Ceberg, Crister LU
; Salford, Leif
LU
; Brun, Arne
LU
; Hemler, Raphael J B
and Persson, Bertil R
LU
(1993)
In Radiotherapy and Oncology
26(2).
p.139-146
- Abstract
- Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for... (More)
- Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107456
- author
- Ceberg, Crister
LU
; Salford, Leif
LU
; Brun, Arne
LU
; Hemler, Raphael J B
and Persson, Bertil R
LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BNCT, Glioma, Bio-distribution, Boron imaging, Track-films, Self-absorption
- in
- Radiotherapy and Oncology
- volume
- 26
- issue
- 2
- pages
- 139 - 146
- publisher
- Elsevier
- external identifiers
-
- pmid:8465014
- scopus:0027477816
- ISSN
- 1879-0887
- DOI
- 10.1016/0167-8140(93)90095-P
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Radiation Physics, Lund (013034000), Pathology, (Lund) (013030000), Neurosurgery (013026000)
- id
- 4fa673f3-5117-461b-bc63-fc637e00e2c8 (old id 1107456)
- date added to LUP
- 2016-04-01 12:27:11
- date last changed
- 2021-01-03 10:15:50
@article{4fa673f3-5117-461b-bc63-fc637e00e2c8,
abstract = {{Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined.}},
author = {{Ceberg, Crister and Salford, Leif and Brun, Arne and Hemler, Raphael J B and Persson, Bertil R}},
issn = {{1879-0887}},
keywords = {{BNCT; Glioma; Bio-distribution; Boron imaging; Track-films; Self-absorption}},
language = {{eng}},
number = {{2}},
pages = {{139--146}},
publisher = {{Elsevier}},
series = {{Radiotherapy and Oncology}},
title = {{Neutron capture imaging of 10B in tissue specimens}},
url = {{http://dx.doi.org/10.1016/0167-8140(93)90095-P}},
doi = {{10.1016/0167-8140(93)90095-P}},
volume = {{26}},
year = {{1993}},
}