Advanced

Necrosis of malignant gliomas after intratumoral injection of 201Tl in vivo in the rat

Sjöholm, H; Ljunggren, Kaj LU ; Adeli, Reza LU ; Brun, Arne LU ; Ceberg, Crister LU ; Strand, Sven-Erik LU and Salford, Leif LU (1995) In Anti-Cancer Drugs 6(1). p.109-114
Abstract
Fourteen adult Fischer 344 rats were inoculated in vivo unilaterally in the caudate nucleus in the brain with malignant RG 2 glioma cells. By 3 weeks a tumor with a diameter of 3-6 mm normally develops. Ten animals which survived the repeated periods of anesthesia and thallium (Tl) injections (intratumorally three times of 201Tl, 15-23 days after inoculation) showed a prolonged retention of radioactivity at the site of injection with no uptake in other organs except for the kidneys. Singular circumscribed necroses were found post-mortem at the site of injection, comprising malignant glioma tumor tissue, which in six animals was absent, in three animals was markedly reduced in size compared with controls and in one animal had the expected... (More)
Fourteen adult Fischer 344 rats were inoculated in vivo unilaterally in the caudate nucleus in the brain with malignant RG 2 glioma cells. By 3 weeks a tumor with a diameter of 3-6 mm normally develops. Ten animals which survived the repeated periods of anesthesia and thallium (Tl) injections (intratumorally three times of 201Tl, 15-23 days after inoculation) showed a prolonged retention of radioactivity at the site of injection with no uptake in other organs except for the kidneys. Singular circumscribed necroses were found post-mortem at the site of injection, comprising malignant glioma tumor tissue, which in six animals was absent, in three animals was markedly reduced in size compared with controls and in one animal had the expected size. In four animals metastases were found in distant locations in the brain; in three of these cases there was a retention of radioactivity in the tumor. The selective necrotizing effect on the tumor cells is interpreted as mainly due to emission of Auger electrons from intracellularly accumulated 201Tl, giving rise to very high energy deposition in the vicinity of the cell nucleus. The results should also have implications for the treatment of human malignant gliomas. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anti-Cancer Drugs
volume
6
issue
1
pages
109 - 114
publisher
Rapid Communications
external identifiers
  • pmid:7756674
  • scopus:0028911748
ISSN
0959-4973
language
English
LU publication?
yes
id
9a332e49-6187-414d-a917-ff74b2ba23e7 (old id 1109470)
date added to LUP
2008-07-28 15:38:22
date last changed
2017-07-30 03:33:35
@article{9a332e49-6187-414d-a917-ff74b2ba23e7,
  abstract     = {Fourteen adult Fischer 344 rats were inoculated in vivo unilaterally in the caudate nucleus in the brain with malignant RG 2 glioma cells. By 3 weeks a tumor with a diameter of 3-6 mm normally develops. Ten animals which survived the repeated periods of anesthesia and thallium (Tl) injections (intratumorally three times of 201Tl, 15-23 days after inoculation) showed a prolonged retention of radioactivity at the site of injection with no uptake in other organs except for the kidneys. Singular circumscribed necroses were found post-mortem at the site of injection, comprising malignant glioma tumor tissue, which in six animals was absent, in three animals was markedly reduced in size compared with controls and in one animal had the expected size. In four animals metastases were found in distant locations in the brain; in three of these cases there was a retention of radioactivity in the tumor. The selective necrotizing effect on the tumor cells is interpreted as mainly due to emission of Auger electrons from intracellularly accumulated 201Tl, giving rise to very high energy deposition in the vicinity of the cell nucleus. The results should also have implications for the treatment of human malignant gliomas.},
  author       = {Sjöholm, H and Ljunggren, Kaj and Adeli, Reza and Brun, Arne and Ceberg, Crister and Strand, Sven-Erik and Salford, Leif},
  issn         = {0959-4973},
  language     = {eng},
  number       = {1},
  pages        = {109--114},
  publisher    = {Rapid Communications},
  series       = {Anti-Cancer Drugs},
  title        = {Necrosis of malignant gliomas after intratumoral injection of 201Tl in vivo in the rat},
  volume       = {6},
  year         = {1995},
}