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Nerve Regeneration In Nerve Grafts Conditioned By Vibration Exposure

Bergman, Stina; Widerberg, Annika LU ; Danielsen, Nils LU ; Lundborg, Göran LU and Dahlin, Lars LU (1995) In Restorative Neurology and Neuroscience 7(3). p.165-169
Abstract
Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the contralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were... (More)
Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the contralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were determined using the pinch reflex test. Two days of vibration did not influence the regeneration, but 5 days of vibration reduced the initial delay period and a slight reduction of regeneration rate was observed. After 5 days of vibration an increased regeneration distance was observed in both models at day 4 p.o. and at day 6 p.o. in vibrated grafts. This study demonstrates that vibration can condition peripheral nerves and this may by caused by local changes in the peripheral nerve trunk and in the neuron itself. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sciatic nerve, Lesion, Regeneration, Transplantation, Vibration, Schwann cell, Conditioning, Rat, Peripheral nerve, Peripheral nervous system, Rodentia, Mammalia, Vertebrata
in
Restorative Neurology and Neuroscience
volume
7
issue
3
pages
165 - 169
publisher
IOS Press
external identifiers
  • scopus:0028916996
ISSN
1878-3627
DOI
10.3233/RNN-1994-7306
language
English
LU publication?
no
id
bd7c5db1-d6a3-436d-b216-ca54675b82a9 (old id 1109654)
date added to LUP
2008-07-29 12:39:14
date last changed
2017-10-17 15:15:42
@article{bd7c5db1-d6a3-436d-b216-ca54675b82a9,
  abstract     = {Regeneration distances were studied in nerves from vibration-exposed limbs. One hind limb of anaesthetized rats was attached to a vibration exciter and exposed to vibration (80 Hz/32 m/s2) for 5 h/day for 2 or 5 days. Seven days after the latest period a 10-mm long nerve graft was taken from the vibrated sciatic nerve and sutured into a corresponding defect in the contralateral sciatic nerve and vice versa, thereby creating two different models within the same animal: (i) regeneration from a freshly transected unvibrated nerve into a vibrated graft and (ii) regeneration from a vibrated nerve into a fresh nerve graft (vibrated recipient side). Four, 6 or 8 days postoperatively (p.o.) the distances achieved by the regenerating axons were determined using the pinch reflex test. Two days of vibration did not influence the regeneration, but 5 days of vibration reduced the initial delay period and a slight reduction of regeneration rate was observed. After 5 days of vibration an increased regeneration distance was observed in both models at day 4 p.o. and at day 6 p.o. in vibrated grafts. This study demonstrates that vibration can condition peripheral nerves and this may by caused by local changes in the peripheral nerve trunk and in the neuron itself.},
  author       = {Bergman, Stina and Widerberg, Annika and Danielsen, Nils and Lundborg, Göran and Dahlin, Lars},
  issn         = {1878-3627},
  keyword      = {Sciatic nerve,Lesion,Regeneration,Transplantation,Vibration,Schwann cell,Conditioning,Rat,Peripheral nerve,Peripheral nervous system,Rodentia,Mammalia,Vertebrata},
  language     = {eng},
  number       = {3},
  pages        = {165--169},
  publisher    = {IOS Press},
  series       = {Restorative Neurology and Neuroscience},
  title        = {Nerve Regeneration In Nerve Grafts Conditioned By Vibration Exposure},
  url          = {http://dx.doi.org/10.3233/RNN-1994-7306},
  volume       = {7},
  year         = {1995},
}