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Anti-inflammatory properties of titanium in the joint environment. An experimental study in rats

Overgaard, Lars; Danielsen, Nils LU and Bjursten, Lars Magnus LU (1998) In Journal of Bone and Joint Surgery 80-B(5). p.888-893
Abstract
Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently... (More)
Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently with inflammatory cells or intermediary compounds. It may be that arthritic synovial tissue produces reactive oxygen intermediates (free radicals) with which titanium has a unique anti-inflammatory interaction in vitro. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Joint Surgery
volume
80-B
issue
5
pages
888 - 893
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • pmid:9768904
ISSN
2044-5377
language
English
LU publication?
yes
id
2a2d5088-2c9e-4912-835e-7a48017637e7 (old id 1112785)
alternative location
http://www.jbjs.org.uk/cgi/reprint/80-B/5/894
date added to LUP
2008-07-11 11:09:22
date last changed
2016-04-15 19:57:42
@article{2a2d5088-2c9e-4912-835e-7a48017637e7,
  abstract     = {Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently with inflammatory cells or intermediary compounds. It may be that arthritic synovial tissue produces reactive oxygen intermediates (free radicals) with which titanium has a unique anti-inflammatory interaction in vitro.},
  author       = {Overgaard, Lars and Danielsen, Nils and Bjursten, Lars Magnus},
  issn         = {2044-5377},
  language     = {eng},
  number       = {5},
  pages        = {888--893},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {Journal of Bone and Joint Surgery},
  title        = {Anti-inflammatory properties of titanium in the joint environment. An experimental study in rats},
  volume       = {80-B},
  year         = {1998},
}