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Bone mineral density in patients with Crohn's disease during long-term treatment with azathioprine

Florén, Claes-Henrik LU ; Ahrén, Bo LU ; Bengtsson, M; Bartosik, Jacek LU and Obrant, Karl LU (1998) In Journal of Internal Medicine 243(2). p.123-126
Abstract
OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (> 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (< 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid... (More)
OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (> 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (< 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid effect on bone mineral density. CONCLUSIONS: Azathioprine does not seem to affect bone mineral density by itself. However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
azathioprine, bone mineral density, corticosteroids, Crohn's disease, prednisolone
in
Journal of Internal Medicine
volume
243
issue
2
pages
123 - 126
publisher
Wiley-Blackwell
external identifiers
  • pmid:9566640
ISSN
1365-2796
language
English
LU publication?
yes
id
f7f4f1ae-2edd-4610-9195-479cbbc4c604 (old id 1113206)
date added to LUP
2008-07-14 14:17:49
date last changed
2016-04-16 04:22:34
@article{f7f4f1ae-2edd-4610-9195-479cbbc4c604,
  abstract     = {OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (&gt; 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (&lt; 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid effect on bone mineral density. CONCLUSIONS: Azathioprine does not seem to affect bone mineral density by itself. However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease.},
  author       = {Florén, Claes-Henrik and Ahrén, Bo and Bengtsson, M and Bartosik, Jacek and Obrant, Karl},
  issn         = {1365-2796},
  keyword      = {azathioprine,bone mineral density,corticosteroids,Crohn's disease,prednisolone},
  language     = {eng},
  number       = {2},
  pages        = {123--126},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Internal Medicine},
  title        = {Bone mineral density in patients with Crohn's disease during long-term treatment with azathioprine},
  volume       = {243},
  year         = {1998},
}