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Low recurrence rate after deep calf-vein thrombosis with 6 weeks of oral anticoagulation

Astermark, Jan LU ; Bjorgell, O; Linden, E; Lethagen, Stefan LU ; Nilsson, P and Berntorp, Erik LU (1998) In Journal of Internal Medicine 244(1). p.79-82
Abstract
OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant... (More)
OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant melanoma. Eight patients (6.3%) reported minor haemorrhagic complications, but no major bleeding was seen. CONCLUSION: Our data support the use of a 6 week regimen of secondary oral prophylaxis after a first episode of deep calf-vein thrombosis in patients without a permanent risk factor. Whether individuals with inherited thrombophilia require prolonged treatment remains to be evaluated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calf-vein thrombosis, oral anticoagulation, recurrence rate
in
Journal of Internal Medicine
volume
244
issue
1
pages
79 - 82
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • pmid:9698028
  • scopus:0031858102
ISSN
1365-2796
DOI
10.1046/j.1365-2796.1998.00318.x
language
English
LU publication?
yes
id
34acf916-32c3-43eb-8d09-d4d3ddb5f981 (old id 1113670)
date added to LUP
2008-07-16 09:43:53
date last changed
2017-11-12 03:53:14
@article{34acf916-32c3-43eb-8d09-d4d3ddb5f981,
  abstract     = {OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant melanoma. Eight patients (6.3%) reported minor haemorrhagic complications, but no major bleeding was seen. CONCLUSION: Our data support the use of a 6 week regimen of secondary oral prophylaxis after a first episode of deep calf-vein thrombosis in patients without a permanent risk factor. Whether individuals with inherited thrombophilia require prolonged treatment remains to be evaluated.},
  author       = {Astermark, Jan and Bjorgell, O and Linden, E and Lethagen, Stefan and Nilsson, P and Berntorp, Erik},
  issn         = {1365-2796},
  keyword      = {calf-vein thrombosis,oral anticoagulation,recurrence rate},
  language     = {eng},
  number       = {1},
  pages        = {79--82},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Low recurrence rate after deep calf-vein thrombosis with 6 weeks of oral anticoagulation},
  url          = {http://dx.doi.org/10.1046/j.1365-2796.1998.00318.x},
  volume       = {244},
  year         = {1998},
}