Low recurrence rate after deep calf-vein thrombosis with 6 weeks of oral anticoagulation
(1998) In Journal of Internal Medicine 244(1). p.79-82- Abstract
- OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant... (More)
- OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant melanoma. Eight patients (6.3%) reported minor haemorrhagic complications, but no major bleeding was seen. CONCLUSION: Our data support the use of a 6 week regimen of secondary oral prophylaxis after a first episode of deep calf-vein thrombosis in patients without a permanent risk factor. Whether individuals with inherited thrombophilia require prolonged treatment remains to be evaluated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1113670
- author
- Astermark, Jan LU ; Bjorgell, O ; Linden, E ; Lethagen, Stefan LU ; Nilsson, P and Berntorp, Erik LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- calf-vein thrombosis, oral anticoagulation, recurrence rate
- in
- Journal of Internal Medicine
- volume
- 244
- issue
- 1
- pages
- 79 - 82
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9698028
- scopus:0031858102
- ISSN
- 1365-2796
- DOI
- 10.1046/j.1365-2796.1998.00318.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Radiology Unit (013241410), Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
- id
- 34acf916-32c3-43eb-8d09-d4d3ddb5f981 (old id 1113670)
- date added to LUP
- 2016-04-01 15:47:21
- date last changed
- 2025-04-04 14:13:05
@article{34acf916-32c3-43eb-8d09-d4d3ddb5f981, abstract = {{OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant melanoma. Eight patients (6.3%) reported minor haemorrhagic complications, but no major bleeding was seen. CONCLUSION: Our data support the use of a 6 week regimen of secondary oral prophylaxis after a first episode of deep calf-vein thrombosis in patients without a permanent risk factor. Whether individuals with inherited thrombophilia require prolonged treatment remains to be evaluated.}}, author = {{Astermark, Jan and Bjorgell, O and Linden, E and Lethagen, Stefan and Nilsson, P and Berntorp, Erik}}, issn = {{1365-2796}}, keywords = {{calf-vein thrombosis; oral anticoagulation; recurrence rate}}, language = {{eng}}, number = {{1}}, pages = {{79--82}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Internal Medicine}}, title = {{Low recurrence rate after deep calf-vein thrombosis with 6 weeks of oral anticoagulation}}, url = {{http://dx.doi.org/10.1046/j.1365-2796.1998.00318.x}}, doi = {{10.1046/j.1365-2796.1998.00318.x}}, volume = {{244}}, year = {{1998}}, }