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Low recurrence rate after deep calf-vein thrombosis with 6 weeks of oral anticoagulation

Astermark, Jan LU ; Bjorgell, O ; Linden, E ; Lethagen, Stefan LU ; Nilsson, P and Berntorp, Erik LU (1998) In Journal of Internal Medicine 244(1). p.79-82
Abstract
OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant... (More)
OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant melanoma. Eight patients (6.3%) reported minor haemorrhagic complications, but no major bleeding was seen. CONCLUSION: Our data support the use of a 6 week regimen of secondary oral prophylaxis after a first episode of deep calf-vein thrombosis in patients without a permanent risk factor. Whether individuals with inherited thrombophilia require prolonged treatment remains to be evaluated. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calf-vein thrombosis, oral anticoagulation, recurrence rate
in
Journal of Internal Medicine
volume
244
issue
1
pages
79 - 82
publisher
Wiley-Blackwell
external identifiers
  • pmid:9698028
  • scopus:0031858102
ISSN
1365-2796
DOI
10.1046/j.1365-2796.1998.00318.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Radiology Unit (013241410), Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
id
34acf916-32c3-43eb-8d09-d4d3ddb5f981 (old id 1113670)
date added to LUP
2016-04-01 15:47:21
date last changed
2025-04-04 14:13:05
@article{34acf916-32c3-43eb-8d09-d4d3ddb5f981,
  abstract     = {{OBJECTIVES: To evaluate the recurrence rate after deep calf-vein thrombosis treated with 6 weeks of oral anticoagulation. DESIGN AND SUBJECTS: A 2 year follow-up of 126 consecutive patients admitted to the Department of Internal Medicine with venographically verified deep calf-vein thrombosis. RESULTS: One hundred and twenty-six patients were treated with warfarin for 6 weeks, 18 of them having had a previous episode of venous thrombosis (DVT). Eleven patients (8.7%) suffered a recurrent thromboembolic episode within 2 years, four of which were within the first 3 months. Eight of those without a history of DVT had a recurrence (7.4%). Three of these were activated protein C (APC)-resistant, one was protein C-deficient and one had malignant melanoma. Eight patients (6.3%) reported minor haemorrhagic complications, but no major bleeding was seen. CONCLUSION: Our data support the use of a 6 week regimen of secondary oral prophylaxis after a first episode of deep calf-vein thrombosis in patients without a permanent risk factor. Whether individuals with inherited thrombophilia require prolonged treatment remains to be evaluated.}},
  author       = {{Astermark, Jan and Bjorgell, O and Linden, E and Lethagen, Stefan and Nilsson, P and Berntorp, Erik}},
  issn         = {{1365-2796}},
  keywords     = {{calf-vein thrombosis; oral anticoagulation; recurrence rate}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{79--82}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Internal Medicine}},
  title        = {{Low recurrence rate after deep calf-vein thrombosis with 6 weeks of oral anticoagulation}},
  url          = {{http://dx.doi.org/10.1046/j.1365-2796.1998.00318.x}},
  doi          = {{10.1046/j.1365-2796.1998.00318.x}},
  volume       = {{244}},
  year         = {{1998}},
}