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Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome

Holm, Johan LU ; Hillarp, Andreas LU ; Zöller, Bengt LU ; Erhardt, Leif RW LU ; Berntorp, Erik LU and Dahlbäck, Björn LU (1999) In Thrombosis and Haemostasis 81(6). p.857-860
Abstract
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The... (More)
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis and Haemostasis
volume
81
issue
6
pages
857 - 860
publisher
F K Schattauer Verlag Gmbh
external identifiers
  • pmid:10404756
  • scopus:0033143554
ISSN
0340-6245
language
English
LU publication?
yes
id
5b4de8b9-a9fd-4478-81a7-cc51163141a3 (old id 1114915)
alternative location
http://www.schattauer.de/index.php?id=788&artikel=13645
date added to LUP
2008-07-07 11:00:02
date last changed
2017-01-01 07:10:58
@article{5b4de8b9-a9fd-4478-81a7-cc51163141a3,
  abstract     = {Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.},
  author       = {Holm, Johan and Hillarp, Andreas and Zöller, Bengt and Erhardt, Leif RW and Berntorp, Erik and Dahlbäck, Björn},
  issn         = {0340-6245},
  language     = {eng},
  number       = {6},
  pages        = {857--860},
  publisher    = {F K Schattauer Verlag Gmbh},
  series       = {Thrombosis and Haemostasis},
  title        = {Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome},
  volume       = {81},
  year         = {1999},
}