Advanced

Malmo International Brother Study (MIBS): an international survey of brother pairs with haemophilia

Astermark, Jan LU and Berntorp, Erik LU (1999) In Vox Sanguinis 77(Suppl. 1). p.80-82
Abstract
Malmo International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non-twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs (27%) there is a history of inhibitors, in 25 of them involving only one of the brothers. Immune tolerance induction has been attempted in 13 brother pairs (27%) and in four pairs the inhibitor has been eradicated. Additional demographic data need to be collected and, if possible plasma, IgG and DNA samples will be taken from inhibitor... (More)
Malmo International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non-twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs (27%) there is a history of inhibitors, in 25 of them involving only one of the brothers. Immune tolerance induction has been attempted in 13 brother pairs (27%) and in four pairs the inhibitor has been eradicated. Additional demographic data need to be collected and, if possible plasma, IgG and DNA samples will be taken from inhibitor patients to serve as a tool for basic inhibitor experiments. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vox Sanguinis
volume
77
issue
Suppl. 1
pages
80 - 82
publisher
Wiley-Blackwell
external identifiers
  • pmid:10529695
  • scopus:0032854688
ISSN
1423-0410
language
English
LU publication?
yes
id
facad312-00b5-4829-a181-5c16adb7ba19 (old id 1115036)
date added to LUP
2008-07-07 12:46:48
date last changed
2017-01-01 07:06:49
@article{facad312-00b5-4829-a181-5c16adb7ba19,
  abstract     = {Malmo International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non-twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs (27%) there is a history of inhibitors, in 25 of them involving only one of the brothers. Immune tolerance induction has been attempted in 13 brother pairs (27%) and in four pairs the inhibitor has been eradicated. Additional demographic data need to be collected and, if possible plasma, IgG and DNA samples will be taken from inhibitor patients to serve as a tool for basic inhibitor experiments.},
  author       = {Astermark, Jan and Berntorp, Erik},
  issn         = {1423-0410},
  language     = {eng},
  number       = {Suppl. 1},
  pages        = {80--82},
  publisher    = {Wiley-Blackwell},
  series       = {Vox Sanguinis},
  title        = {Malmo International Brother Study (MIBS): an international survey of brother pairs with haemophilia},
  volume       = {77},
  year         = {1999},
}