Malmo International Brother Study (MIBS): an international survey of brother pairs with haemophilia
(1999) In Vox Sanguinis 77(Suppl. 1). p.80-82- Abstract
- Malmo International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non-twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs (27%) there is a history of inhibitors, in 25 of them involving only one of the brothers. Immune tolerance induction has been attempted in 13 brother pairs (27%) and in four pairs the inhibitor has been eradicated. Additional demographic data need to be collected and, if possible plasma, IgG and DNA samples will be taken from inhibitor... (More)
- Malmo International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non-twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs (27%) there is a history of inhibitors, in 25 of them involving only one of the brothers. Immune tolerance induction has been attempted in 13 brother pairs (27%) and in four pairs the inhibitor has been eradicated. Additional demographic data need to be collected and, if possible plasma, IgG and DNA samples will be taken from inhibitor patients to serve as a tool for basic inhibitor experiments. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1115036
- author
- Astermark, Jan LU and Berntorp, Erik LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Vox Sanguinis
- volume
- 77
- issue
- Suppl. 1
- pages
- 80 - 82
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10529695
- scopus:0032854688
- ISSN
- 1423-0410
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
- id
- facad312-00b5-4829-a181-5c16adb7ba19 (old id 1115036)
- date added to LUP
- 2016-04-01 16:29:39
- date last changed
- 2022-01-28 20:06:50
@article{facad312-00b5-4829-a181-5c16adb7ba19, abstract = {{Malmo International Brother Study (MIBS) was initiated in 1996 in order to set up an international registry of twins and non-twin brothers with haemophilia and to search for genetic and compound factors predisposing for inhibitor development. As of July, 1997, 178 brother pairs are registered (143 haemophilia A and 35 haemophilia B patients). Sixteen of these pairs are twins. In 48 of the brother pairs (27%) there is a history of inhibitors, in 25 of them involving only one of the brothers. Immune tolerance induction has been attempted in 13 brother pairs (27%) and in four pairs the inhibitor has been eradicated. Additional demographic data need to be collected and, if possible plasma, IgG and DNA samples will be taken from inhibitor patients to serve as a tool for basic inhibitor experiments.}}, author = {{Astermark, Jan and Berntorp, Erik}}, issn = {{1423-0410}}, language = {{eng}}, number = {{Suppl. 1}}, pages = {{80--82}}, publisher = {{Wiley-Blackwell}}, series = {{Vox Sanguinis}}, title = {{Malmo International Brother Study (MIBS): an international survey of brother pairs with haemophilia}}, volume = {{77}}, year = {{1999}}, }