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Concentrations of plasma methylmalonic acid in 80-year-olds show only weak relation to psychological performance

Hultberg, Björn LU ; Jensen, Elmo; Dehlin, Ove LU ; Hagberg, Bo LU ; Samuelsson, Gillis LU and Svensson, Torbjörn LU (1999) In Clinical Chemistry and Laboratory Medicine 37(10). p.963-967
Abstract
Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic acid, have attracted growing interest since they are considered to reflect the status of cobalamins and folates in the tissues. In a previous study, we noted a strong association between five parameters of well-being and lower concentrations of plasma homocysteine. In the present study, we have extended these observations by determination of plasma methylmalonic acid in the same healthy elderly population. In the present... (More)
Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic acid, have attracted growing interest since they are considered to reflect the status of cobalamins and folates in the tissues. In a previous study, we noted a strong association between five parameters of well-being and lower concentrations of plasma homocysteine. In the present study, we have extended these observations by determination of plasma methylmalonic acid in the same healthy elderly population. In the present study, 18 out of 100 subjects had increased plasma methylmalonic acid and in 7 of these subjects, the concentrations of serum cobalamin, blood folate, plasma homocysteine and serum creatinine were within normal limits. The relation between plasma methylmalonic acid concentrations and concentrations of serum cobalamin and blood folates and five parameters of well-being were investigated. Concentrations of plasma methylmalonic acid were only weakly associated with the concentrations of serum cobalamin and lower scores on the logical reasoning test. The present study clearly shows that the levels of plasma methylmalonic acid show a much lesser association with the parameters of well-being than did plasma homocysteine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Elderly, Methylmalonic acid, Plasma, Psychology, Quality of life
in
Clinical Chemistry and Laboratory Medicine
volume
37
issue
10
pages
963 - 967
publisher
De Gruyter
external identifiers
  • pmid:10616750
  • scopus:0033453247
ISSN
1434-6621
DOI
10.1515/CCLM.1999.142
language
English
LU publication?
yes
id
97fa1a39-38a4-43d9-8e57-6caa090cd37e (old id 1115509)
date added to LUP
2008-07-08 10:30:28
date last changed
2017-01-01 04:24:01
@article{97fa1a39-38a4-43d9-8e57-6caa090cd37e,
  abstract     = {Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic acid, have attracted growing interest since they are considered to reflect the status of cobalamins and folates in the tissues. In a previous study, we noted a strong association between five parameters of well-being and lower concentrations of plasma homocysteine. In the present study, we have extended these observations by determination of plasma methylmalonic acid in the same healthy elderly population. In the present study, 18 out of 100 subjects had increased plasma methylmalonic acid and in 7 of these subjects, the concentrations of serum cobalamin, blood folate, plasma homocysteine and serum creatinine were within normal limits. The relation between plasma methylmalonic acid concentrations and concentrations of serum cobalamin and blood folates and five parameters of well-being were investigated. Concentrations of plasma methylmalonic acid were only weakly associated with the concentrations of serum cobalamin and lower scores on the logical reasoning test. The present study clearly shows that the levels of plasma methylmalonic acid show a much lesser association with the parameters of well-being than did plasma homocysteine.},
  author       = {Hultberg, Björn and Jensen, Elmo and Dehlin, Ove and Hagberg, Bo and Samuelsson, Gillis and Svensson, Torbjörn},
  issn         = {1434-6621},
  keyword      = {Elderly,Methylmalonic acid,Plasma,Psychology,Quality of life},
  language     = {eng},
  number       = {10},
  pages        = {963--967},
  publisher    = {De Gruyter},
  series       = {Clinical Chemistry and Laboratory Medicine},
  title        = {Concentrations of plasma methylmalonic acid in 80-year-olds show only weak relation to psychological performance},
  url          = {http://dx.doi.org/10.1515/CCLM.1999.142},
  volume       = {37},
  year         = {1999},
}