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Calcitonin and calcitonin gene-related peptide in the human prostate gland

Abrahamsson, Per-Anders LU ; Dizeyi, Nishtman LU ; Alm, Per LU ; di Sant'Agnese, P A; Deftos, L J and Aumuller, G (2000) In The Prostate 44(3). p.181-186
Abstract
BACKGROUND: Calcitonin-related peptides have been found in the human prostate, and calcitonin (CT) and calcitonin gene-related peptide (CGRP) have been demonstrated in subpopulations of neuroendocrine (NE) cells. The purpose of this study was to determine the concentrations of CT and CGRP as well as the densities of NE cells in normal prostates, benign prostatic hyperplasia (BPH), and carcinoma of the prostate (CAP). METHODS: In 42 specimens of radical prostatectomy, the number of CT- and CGRP-immunoreactive NE cells in areas of normal and BPH tissue was determined, and compared with CAP tissue using immunocytochemistry. In addition, by radioimmunoassay (RIA), tissue levels of CT and CGRP were analyzed in extracts from areas of normal,... (More)
BACKGROUND: Calcitonin-related peptides have been found in the human prostate, and calcitonin (CT) and calcitonin gene-related peptide (CGRP) have been demonstrated in subpopulations of neuroendocrine (NE) cells. The purpose of this study was to determine the concentrations of CT and CGRP as well as the densities of NE cells in normal prostates, benign prostatic hyperplasia (BPH), and carcinoma of the prostate (CAP). METHODS: In 42 specimens of radical prostatectomy, the number of CT- and CGRP-immunoreactive NE cells in areas of normal and BPH tissue was determined, and compared with CAP tissue using immunocytochemistry. In addition, by radioimmunoassay (RIA), tissue levels of CT and CGRP were analyzed in extracts from areas of normal, BPH, and CAP tissue, as verified by adjacent histologic sections. RESULTS: A significant decrease in CT-immunoreactive NE cells was observed in hyperplastic nodules of BPH in comparison to normal tissue. These findings were in parallel with a significant reduction in tissue CT level in BPH compared to normal tissue. There was also a marked, but statistically nonsignificant, reduction in CT levels in CAP tissue. In contrast, levels of CGRP in BPH and CAP tissue did not show any significant differences compared to normal tissue. CONCLUSIONS: CT and CGRP are present in NE cells of the human prostate. Calcitonin levels are significantly reduced in BPH, in parallel with a decreased number of CT-immunoreactive NE cells, whereas no significant changes in tissue levels of CGRP were observed. The functional significance of these findings is discussed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neuroendocrine cells, prostatic hyperplasia, prostatic carcinoma
in
The Prostate
volume
44
issue
3
pages
181 - 186
publisher
John Wiley & Sons
external identifiers
  • pmid:10906733
  • scopus:0034255651
ISSN
0270-4137
DOI
10.1002/1097-0045(20000801)44:3<181::AID-PROS1>3.0.CO;2-L
language
English
LU publication?
yes
id
4593e9db-5ee7-462e-92bb-d98dc396f2c1 (old id 1116242)
date added to LUP
2008-07-01 10:48:57
date last changed
2017-01-01 04:57:23
@article{4593e9db-5ee7-462e-92bb-d98dc396f2c1,
  abstract     = {BACKGROUND: Calcitonin-related peptides have been found in the human prostate, and calcitonin (CT) and calcitonin gene-related peptide (CGRP) have been demonstrated in subpopulations of neuroendocrine (NE) cells. The purpose of this study was to determine the concentrations of CT and CGRP as well as the densities of NE cells in normal prostates, benign prostatic hyperplasia (BPH), and carcinoma of the prostate (CAP). METHODS: In 42 specimens of radical prostatectomy, the number of CT- and CGRP-immunoreactive NE cells in areas of normal and BPH tissue was determined, and compared with CAP tissue using immunocytochemistry. In addition, by radioimmunoassay (RIA), tissue levels of CT and CGRP were analyzed in extracts from areas of normal, BPH, and CAP tissue, as verified by adjacent histologic sections. RESULTS: A significant decrease in CT-immunoreactive NE cells was observed in hyperplastic nodules of BPH in comparison to normal tissue. These findings were in parallel with a significant reduction in tissue CT level in BPH compared to normal tissue. There was also a marked, but statistically nonsignificant, reduction in CT levels in CAP tissue. In contrast, levels of CGRP in BPH and CAP tissue did not show any significant differences compared to normal tissue. CONCLUSIONS: CT and CGRP are present in NE cells of the human prostate. Calcitonin levels are significantly reduced in BPH, in parallel with a decreased number of CT-immunoreactive NE cells, whereas no significant changes in tissue levels of CGRP were observed. The functional significance of these findings is discussed.},
  author       = {Abrahamsson, Per-Anders and Dizeyi, Nishtman and Alm, Per and di Sant'Agnese, P A and Deftos, L J and Aumuller, G},
  issn         = {0270-4137},
  keyword      = {neuroendocrine cells,prostatic hyperplasia,prostatic carcinoma},
  language     = {eng},
  number       = {3},
  pages        = {181--186},
  publisher    = {John Wiley & Sons},
  series       = {The Prostate},
  title        = {Calcitonin and calcitonin gene-related peptide in the human prostate gland},
  url          = {http://dx.doi.org/10.1002/1097-0045(20000801)44:3<181::AID-PROS1>3.0.CO;2-L},
  volume       = {44},
  year         = {2000},
}