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Regional cerebral blood flow distributions in normal volunteers: dynamic susceptibility contrast MRI compared with 99mTc-HMPAO SPECT

Wirestam, Ronnie LU ; Ryding, Erik LU ; Lindgren, Arne LU ; Geijer, Bo LU ; Ostergaard, Leif; Knutsson, Linda LU ; Holtås, Stig LU and Ståhlberg, Freddy LU (2000) In Journal of Computer Assisted Tomography 24(4). p.526-530
Abstract
PURPOSE: Relative regional cerebral blood flow (rCBF) at rest was measured in 44 volunteers using both dynamic susceptibility contrast (DSC) MRI and (99m)Tc-HMPAO SPECT on the same day. METHOD: In MRI, a Gd-DTPA-BMA contrast agent bolus (0.3 mmol/kg body wt) was monitored with a simultaneous dual FLASH pulse sequence (time resolution 1.5 s). MRI-based rCBF images were calculated by singular value decomposition-based deconvolution of the measured tissue concentration-time curve with an arterial input function from a small artery within the imaging slice. In the SPECT investigation, 900 MBq of (99m)Tc-HMPAO was injected intravenously. Relative rCBF in gray matter in the thalamus and in frontal white matter was determined. RESULTS: The ratio... (More)
PURPOSE: Relative regional cerebral blood flow (rCBF) at rest was measured in 44 volunteers using both dynamic susceptibility contrast (DSC) MRI and (99m)Tc-HMPAO SPECT on the same day. METHOD: In MRI, a Gd-DTPA-BMA contrast agent bolus (0.3 mmol/kg body wt) was monitored with a simultaneous dual FLASH pulse sequence (time resolution 1.5 s). MRI-based rCBF images were calculated by singular value decomposition-based deconvolution of the measured tissue concentration-time curve with an arterial input function from a small artery within the imaging slice. In the SPECT investigation, 900 MBq of (99m)Tc-HMPAO was injected intravenously. Relative rCBF in gray matter in the thalamus and in frontal white matter was determined. RESULTS: The ratio of relative rCBF in gray matter to relative rCBF in white matter was 2.21 +/- 0.57 using MRI and 2.24 +/- 0.54 using SPECT (mean +/- SD). CONCLUSION: Relative rCBF maps from DSC MRI and (99m)Tc-HMPAO SPECT showed good agreement, and the MRI-based rCBF ratio correlated with the corresponding SPECT-based ratio (r = 0.79, p < 0.0000006). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Computer Assisted Tomography
volume
24
issue
4
pages
526 - 530
publisher
Raven Press
external identifiers
  • pmid:10966181
  • scopus:0034468663
ISSN
1532-3145
language
English
LU publication?
yes
id
8712352a-a9bd-41f8-8ef1-d04d3571cf3f (old id 1116283)
date added to LUP
2008-07-01 11:17:49
date last changed
2017-07-30 03:35:24
@article{8712352a-a9bd-41f8-8ef1-d04d3571cf3f,
  abstract     = {PURPOSE: Relative regional cerebral blood flow (rCBF) at rest was measured in 44 volunteers using both dynamic susceptibility contrast (DSC) MRI and (99m)Tc-HMPAO SPECT on the same day. METHOD: In MRI, a Gd-DTPA-BMA contrast agent bolus (0.3 mmol/kg body wt) was monitored with a simultaneous dual FLASH pulse sequence (time resolution 1.5 s). MRI-based rCBF images were calculated by singular value decomposition-based deconvolution of the measured tissue concentration-time curve with an arterial input function from a small artery within the imaging slice. In the SPECT investigation, 900 MBq of (99m)Tc-HMPAO was injected intravenously. Relative rCBF in gray matter in the thalamus and in frontal white matter was determined. RESULTS: The ratio of relative rCBF in gray matter to relative rCBF in white matter was 2.21 +/- 0.57 using MRI and 2.24 +/- 0.54 using SPECT (mean +/- SD). CONCLUSION: Relative rCBF maps from DSC MRI and (99m)Tc-HMPAO SPECT showed good agreement, and the MRI-based rCBF ratio correlated with the corresponding SPECT-based ratio (r = 0.79, p &lt; 0.0000006).},
  author       = {Wirestam, Ronnie and Ryding, Erik and Lindgren, Arne and Geijer, Bo and Ostergaard, Leif and Knutsson, Linda and Holtås, Stig and Ståhlberg, Freddy},
  issn         = {1532-3145},
  language     = {eng},
  number       = {4},
  pages        = {526--530},
  publisher    = {Raven Press},
  series       = {Journal of Computer Assisted Tomography},
  title        = {Regional cerebral blood flow distributions in normal volunteers: dynamic susceptibility contrast MRI compared with 99mTc-HMPAO SPECT},
  volume       = {24},
  year         = {2000},
}