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Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques

Wirestam, Ronnie LU ; Knutsson, Linda LU ; Ostergaard, Leif; Bolling, Max; Aunola, Juha-Petri; Lindgren, Arne LU ; Geijer, Bo LU ; Holtås, Stig LU and Ståhlberg, Freddy LU (2000) In Magnetic Resonance in Medicine 43(5). p.691-700
Abstract
Regional cerebral blood flow (rCBF) was assessed using dynamic susceptibility-contrast MRI at 1.5 T. A simultaneous dual FLASH pulse sequence and Gd-DTPA-BMA (0.3 mmol/kg b.w.) were used for examination of 43 volunteers, measuring rCBF in frontal white matter (WM) and in gray matter in the thalamus (GM). Arterial input functions (AIFs) were registered 1) in the carotid artery and 2) in an artery within the GM/WM slice. The measured concentration-vs. -time curve was deconvolved with the AIF using both Fourier Transform (FT) and Singular Value Decomposition (SVD). Relative rCBF was given by the height of the deconvolved response curve. For each volunteer, eight different rCBF maps were calculated, representing different combinations of... (More)
Regional cerebral blood flow (rCBF) was assessed using dynamic susceptibility-contrast MRI at 1.5 T. A simultaneous dual FLASH pulse sequence and Gd-DTPA-BMA (0.3 mmol/kg b.w.) were used for examination of 43 volunteers, measuring rCBF in frontal white matter (WM) and in gray matter in the thalamus (GM). Arterial input functions (AIFs) were registered 1) in the carotid artery and 2) in an artery within the GM/WM slice. The measured concentration-vs. -time curve was deconvolved with the AIF using both Fourier Transform (FT) and Singular Value Decomposition (SVD). Relative rCBF was given by the height of the deconvolved response curve. For each volunteer, eight different rCBF maps were calculated, representing different combinations of deconvolution techniques, AIFs, and filters. The average GM-WM rCBF ratios ranged from 2.0-2.2, depending on methodology. Absolute rCBF was 68 +/- 28 ml/(min 100 g) in GM and 35 +/- 13 ml/(min 100g) in WM (mean +/- SD, n = 39). GM-WM rCBF ratios obtained using SVD were 6-10% higher than corresponding ratios obtained using FT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral blood flow (CBF), dynamic susceptibility-contrast magnetic resonance imaging (MRI), nonparametric deconvolution, arterial input function
in
Magnetic Resonance in Medicine
volume
43
issue
5
pages
691 - 700
publisher
Wiley Online Library
external identifiers
  • pmid:10800034
  • scopus:0034063886
ISSN
1522-2594
DOI
10.1002/(SICI)1522-2594(200005)43:5<691::AID-MRM11>3.0.CO;2-B
language
English
LU publication?
yes
id
5e61b821-9cfd-42d1-9529-724bf148c5c5 (old id 1116291)
date added to LUP
2008-07-01 11:23:41
date last changed
2017-01-01 04:56:39
@article{5e61b821-9cfd-42d1-9529-724bf148c5c5,
  abstract     = {Regional cerebral blood flow (rCBF) was assessed using dynamic susceptibility-contrast MRI at 1.5 T. A simultaneous dual FLASH pulse sequence and Gd-DTPA-BMA (0.3 mmol/kg b.w.) were used for examination of 43 volunteers, measuring rCBF in frontal white matter (WM) and in gray matter in the thalamus (GM). Arterial input functions (AIFs) were registered 1) in the carotid artery and 2) in an artery within the GM/WM slice. The measured concentration-vs. -time curve was deconvolved with the AIF using both Fourier Transform (FT) and Singular Value Decomposition (SVD). Relative rCBF was given by the height of the deconvolved response curve. For each volunteer, eight different rCBF maps were calculated, representing different combinations of deconvolution techniques, AIFs, and filters. The average GM-WM rCBF ratios ranged from 2.0-2.2, depending on methodology. Absolute rCBF was 68 +/- 28 ml/(min 100 g) in GM and 35 +/- 13 ml/(min 100g) in WM (mean +/- SD, n = 39). GM-WM rCBF ratios obtained using SVD were 6-10% higher than corresponding ratios obtained using FT.},
  author       = {Wirestam, Ronnie and Knutsson, Linda and Ostergaard, Leif and Bolling, Max and Aunola, Juha-Petri and Lindgren, Arne and Geijer, Bo and Holtås, Stig and Ståhlberg, Freddy},
  issn         = {1522-2594},
  keyword      = {cerebral blood flow (CBF),dynamic susceptibility-contrast magnetic resonance imaging (MRI),nonparametric deconvolution,arterial input function},
  language     = {eng},
  number       = {5},
  pages        = {691--700},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques},
  url          = {http://dx.doi.org/10.1002/(SICI)1522-2594(200005)43:5<691::AID-MRM11>3.0.CO;2-B},
  volume       = {43},
  year         = {2000},
}